Mitogen-activated protein kinase kinase kinase kinase 2 (Map4k2) Recombinant Protein | Map4k2 recombinant protein

Recombinant Mouse Mitogen-activated protein kinase kinase kinase kinase 2 (Map4k2) , partial

• Gene Names: Map4k2; GCK; BL44; Rab8ip; AI385662
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Mitogen-activated protein kinase kinase kinase kinase 2 (Map4k2); Recombinant Mouse Mitogen-activated protein kinase kinase kinase kinase 2 (Map4k2); partial; Map4k2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 821

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Map4k2 recombinant protein

This protein is a member of the serine
threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1
MEKK1.

NCBI and Uniprot Product Information

• NCBI GI #: 619534148
• NCBI GeneID: 26412
• NCBI Accession #: NP_001278716.1
• NCBI GenBank Nucleotide #: NM_001291787.1
• UniProt Accession #: Q61161
• Molecular Weight: 91,265 Da
• NCBI Official Full Name: mitogen-activated protein kinase kinase kinase kinase 2 isoform 2
• NCBI Official Synonym Full Names: mitogen-activated protein kinase kinase kinase kinase 2
• NCBI Official Symbol: Map4k2
• NCBI Official Synonym Symbols: GCK; BL44; Rab8ip; AI385662
• NCBI Protein Information: mitogen-activated protein kinase kinase kinase kinase 2
• UniProt Protein Name: Mitogen-activated protein kinase kinase kinase kinase 2
• Protein Family: Mitogen-activated protein kinase kinase kinase kinase
• UniProt Gene Name: Map4k2
• UniProt Synonym Gene Names: Rab8ip; GCK; MEK kinase kinase 2; MEKKK 2

Uniprot Description

Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN),or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion.