MLK1 Blocking Peptide | MAP3K9 blocking peptide
MLK1 Antibody (C-term) Blocking Peptide
Gene Names
MAP3K9; MLK1; MEKK9; PRKE1
Synonyms
MLK1; MLK1 Antibody (C-term) Blocking Peptide; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; MAP3K9; PRKE1; MAP3K9 blocking peptide
Specificity
The synthetic peptide sequence is selected from aa 1046~1066 of human MLK1.
Form/Format
The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Sequence Length
1104
Tissue Location
Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for MAP3K9 blocking peptide
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
123,373 Da
NCBI Official Full Name
Mitogen-activated protein kinase kinase kinase 9
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase kinase 9
NCBI Official Symbol
MAP3K9
NCBI Official Synonym Symbols
MLK1; MEKK9; PRKE1
NCBI Protein Information
mitogen-activated protein kinase kinase kinase 9
UniProt Protein Name
Mitogen-activated protein kinase kinase kinase 9
Protein Family
UniProt Gene Name
MAP3K9
UniProt Synonym Gene Names
MLK1; PRKE1
UniProt Entry Name
M3K9_HUMAN
Uniprot Description
MLK1: a TKL kinase of the MLK family. A dual leucine zipper kinase. Expressed in neuronal cells and may act between Rac1/Cdc42 and MKK4 and -7 in death signaling.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; Protein kinase, TKL; TKL group; MLK family; MLK subfamily
Chromosomal Location of Human Ortholog: 14q24.2
Molecular Function: JUN kinase kinase kinase activity; protein binding; protein homodimerization activity; protein serine/threonine kinase activity
Biological Process: activation of JNK activity; protein amino acid autophosphorylation; protein amino acid phosphorylation
Research Articles on MAP3K9
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Product Notes
The MAP3K9 map3k9 (Catalog #AAA9227378) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MLK1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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