Human mitogen-activated protein kinase kinase kinase 7 interacting protein 1 ELISA Kit | MAP3K7IP1 elisa kit
Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, MAP3K7IP1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
TAB1: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Activator
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: nucleoplasm; protein complex; cytoplasm; endosome membrane; cytosol
Molecular Function: protein binding; mitogen-activated protein kinase p38 binding; enzyme activator activity; kinase activator activity; protein complex binding; catalytic activity
Biological Process: heart morphogenesis; I-kappaB kinase/NF-kappaB cascade; activation of MAPK activity; in utero embryonic development; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; transforming growth factor beta receptor signaling pathway; activation of MAPKKK activity; toll-like receptor signaling pathway; innate immune response; JNK cascade; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway; lung development
Research Articles on MAP3K7IP1
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Product Notes
The Human MAP3K7IP1 tab1 (Catalog #AAA9322377) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9322377 ELISA Kit recognizes Human MAP3K7IP1. It is sometimes possible for the material contained within the vial of "mitogen-activated protein kinase kinase kinase 7 interacting protein 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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