Mannosidase II Blocking Peptide | MAN2A1 blocking peptide
Mannosidase II Blocking Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]
Uniprot Description
MAN2A1: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. Belongs to the glycosyl hydrolase 38 family.
Protein type: Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; EC 3.2.1.114; Hydrolase
Chromosomal Location of Human Ortholog: 5q21.3
Cellular Component: Golgi membrane; cis-Golgi network; membrane; integral to membrane
Molecular Function: hydrolase activity, hydrolyzing N-glycosyl compounds; zinc ion binding; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity; carbohydrate binding
Biological Process: mannose metabolic process; mitochondrion organization and biogenesis; positive regulation of neurogenesis; cellular protein metabolic process; in utero embryonic development; protein amino acid N-linked glycosylation via asparagine; respiratory gaseous exchange; N-glycan processing; liver development; post-translational protein modification; alveolus development; retina morphogenesis in camera-type eye; vacuole organization and biogenesis
Research Articles on MAN2A1
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Product Notes
The MAN2A1 man2a1 (Catalog #AAA9621963) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Mannosidase II can be used in a range of immunoassay formats including, but not limited to, Blocking/Control. Researchers should empirically determine the suitability of the MAN2A1 man2a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Mannosidase II, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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