Human mucosa associated lymphoid tissue lymphoma translocation gene 1 ELISA Kit | MALT1 elisa kit
Human Mucosa-associated lymphoid tissue lymphoma transloCation protein 1, MALT1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
MALT1: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6. Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. Belongs to the peptidase C14B family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear export; Apoptosis; EC 3.4.22.-; Protease; Ligase; Ubiquitin conjugating system; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 18q21
Cellular Component: CBM complex; protein complex; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nucleolus; nucleus; cytosol
Molecular Function: peptidase activity; protein binding; signal transducer activity; protease binding; protein self-association; cysteine-type endopeptidase activity; kinase activator activity; ubiquitin-protein ligase activity
Biological Process: response to fungus; positive regulation of I-kappaB kinase/NF-kappaB cascade; nuclear export; activation of NF-kappaB-inducing kinase; protein ubiquitination; positive regulation of T cell cytokine production; defense response; proteolysis; T cell receptor signaling pathway; protein oligomerization; activation of NF-kappaB transcription factor; regulation of apoptosis; T cell proliferation; B-1 B cell differentiation; positive regulation of protein ubiquitination; regulation of T cell receptor signaling pathway; response to molecule of bacterial origin; positive regulation of interleukin-2 production; innate immune response; positive regulation of T cell activation; negative regulation of apoptosis
Disease: Immunodeficiency 12
Research Articles on MALT1
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Product Notes
The Human MALT1 malt1 (Catalog #AAA9338753) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9338753 ELISA Kit recognizes Human MALT1. It is sometimes possible for the material contained within the vial of "mucosa associated lymphoid tissue lymphoma translocation gene 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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