Melanoma-associated antigen D2 (MAGED2) Recombinant Protein | MAGED2 recombinant protein

Recombinant Human Melanoma-associated antigen D2 (MAGED2)

Cat. Num. AAA1391389

• Gene Names: MAGED2; 11B6; BCG1; BCG-1; HCA10; BARTS5; MAGE-D2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Melanoma-associated antigen D2 (MAGED2); Recombinant Human Melanoma-associated antigen D2 (MAGED2); MAGED2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 2-606, Full length protein
• Sequence: SDTSESGAGLTRFQAEASEKDSSSMMQTLLTVTQNVEVPETPKASKALEVSEDVKVSKASGVSKATEVSKTPEAREAPATQASSTTQLTDTQVLAAENKSLAADTKKQNADPQAVTMPATETKKVSHVADTKVNTKAQETEAAPSQAPADEPEPESAAAQSQENQDTRPKVKAKKARKVKHLDGEEDGSSDQSQASGTTGGRRVSKALMASMARRASRGPIAFWARRASRTRLAAWARRALLSLRSPKARRGKARRRAAKLQSSQEPEAPPPRDVALLQGRANDLVKYLLAKDQTKIPIKRSDMLKDIIKEYTDVYPEIIERAGYSLEKVFGIQLKEIDKNDHLYILLSTLEPTDAGILGTTKDSPKLGLLMVLLSIIFMNGNRSSEAVIWEVLRKLGLRPGIHHSLFGDVKKLITDEFVKQKYLDYARVPNSNPPEYEFFWGLRSYYETSKMKVLKFACKVQKKDPKEWAAQYREAMEADLKAAAEAAAEAKARAEIRARMGIGLGSENAAGPCNWDEADIGPWAKARIQAGAEAKAKAQESGSASTGASTSTNNSASASASTSGGFSAGASLTATLTFGLFAGLGGAGASTSGSSGACGFSYK
• Sequence Length: 605

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for MAGED2 recombinant protein

This gene is a member of the MAGED gene family. While the MAGEA and MAGEB genes are silent in normal tissues with the exception of testis and placenta, the MAGED genes are expressed ubiquitously. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked mental retardation (XLMR). Multiple alternatively spliced transcript variants have been found for this gene, however, the full length nature of some variants has not been defined.

NCBI and Uniprot Product Information

• NCBI GI #: 19387846
• NCBI GeneID: 10916
• NCBI Accession #: NP_055414.2
• NCBI GenBank Nucleotide #: NM_014599.5
• UniProt Accession #: Q9UNF1; O76058; Q5BJF3; Q8NAL6; Q9H218; Q9P0U9; Q9UM52; A6NMX0
• Molecular Weight: 63,167 Da
• NCBI Official Full Name: melanoma-associated antigen D2
• NCBI Official Synonym Full Names: MAGE family member D2
• NCBI Official Symbol: MAGED2
• NCBI Official Synonym Symbols: 11B6; BCG1; BCG-1; HCA10; BARTS5; MAGE-D2
• NCBI Protein Information: melanoma-associated antigen D2
• UniProt Protein Name: Melanoma-associated antigen D2
• Protein Family: Melanoma-associated antigen
• UniProt Gene Name: MAGED2
• UniProt Synonym Gene Names: BCG1; BCG-1

NCBI Description

This gene is a member of the MAGED gene family. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked intellectual disability (XLID). Mutations in this gene cause a form of transient antenatal Bartter's syndrome. This gene may also be involved in several types of cancer, including breast cancer and melanoma. The protein encoded by this gene is progressively recruited from the cytoplasm to the nucleoplasm during the interphase and after nucleolar stress and is thus thought to play a role in cell cycle regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

Uniprot Description

Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule.