Melanoma-associated antigen 1 (MAGEA1) Recombinant Protein | MAGEA1 recombinant protein

Recombinant Human Melanoma-associated antigen 1 (MAGEA1)

Cat. Num. AAA7135770

• Gene Names: MAGEA1; CT1.1; MAGE1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Melanoma-associated antigen 1 (MAGEA1); Recombinant Human Melanoma-associated antigen 1 (MAGEA1); Antigen MZ2-E (Cancer/testis antigen 1.1); (CT1.1); (MAGE-1 antigen); (MAGE1); (MAGE1A); MAGEA1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid or Lyophilized powder; If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.; If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, p
• Sequence Positions: 1-309aa; Full Length of BC017555.1
• Sequence: MSLEQRSLHCKPEEALEAQQEALGLVCVQAATSSSSPLVLGTLEEVPTAGSTDPPQSPQGASAFPTTINFTRQRQPSEGSSSREEEGPSTSCILESLFRAVITKKVADLVGFLLLKYRAREPVTKAEMLESVIKNYKHCFPEIFGKASESLQLVFGIDVKEADPTGHSYVLVTCLGLSYDGLLGDNQIMPKTGFLIIVLVMIAMEGGHAPEEEIWEELSVMEVYDGREHSAYGEPRKLLTQDLVQEKYLEYRQVPDSDPARYEFLWGPRALAETSYVKVLEYVIKVSARVRFFFPSLREAALREEEEGV
• Sequence Length: 309

• Species: Human
• Tag: C-terminal FC-tagged
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 degree C/-80 degree C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Preparation and Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. ; Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C.; The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.; Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for MAGEA1 recombinant protein

May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Product Categories/Family for MAGEA1 recombinant protein

Cancer

References

"Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes."
Gaugler B., van den Eynde B., van der Bruggen P., Romero P., Gaforio J.J., De Plaen E., Lethe B.G., Brasseur F., Boon T.J. Exp. Med. 179:921-930(1994)

NCBI and Uniprot Product Information

• NCBI GI #: 148276977
• NCBI GeneID: 4100
• NCBI Accession #: NP_004979.3
• NCBI GenBank Nucleotide #: NP_004979.3
• UniProt Accession #: P43355
• Molecular Weight: 63.2kDa
• NCBI Official Full Name: melanoma-associated antigen 1
• NCBI Official Synonym Full Names: MAGE family member A1
• NCBI Official Symbol: MAGEA1
• NCBI Official Synonym Symbols: CT1.1; MAGE1
• NCBI Protein Information: melanoma-associated antigen 1
• UniProt Protein Name: Melanoma-associated antigen 1
• Protein Family: Melanoma-associated antigen
• UniProt Gene Name: MAGEA1
• UniProt Synonym Gene Names: MAGE1; MAGE1A; CT1.1
• UniProt Entry Name: MAGA1_HUMAN

NCBI Description

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]

Uniprot Description

MAGE-A1: a tumor antigen expressed in a variety of tumor cells and in the testis. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Protein type: Cell surface

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; histone deacetylase binding

Biological Process: transcription, DNA-dependent; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter