Macrophage Erythroblast Attacher Recombinant Protein | MAEA recombinant protein

Recombinant Human Macrophage Erythroblast Attacher

Cat. Num. AAA146159

• Gene Names: MAEA; EMP; EMLP; GID9; PIG5; HLC-10
• Purity: Greater than 85% as determined by SDS-PAGE.
• Synonyms: Macrophage Erythroblast Attacher; Recombinant Human Macrophage Erythroblast Attacher; MAEA Human; Macrophage Erythroblast Attacher Human Recombinant; GID Complex Subunit 9 FYV10 Homolog; Lung Cancer-Related Protein 10; Proliferation-Inducing Gene 5; Human Lung Cancer Oncogene 10 Protein; Cell Proliferation-Inducing Gene 5 Protein; Erythroblast Macrophage Protein; FYV10 Homolog (S. Cerevisiae); GID Complex Subunit 9; EMLP; GID9; PIG5; HLC-10; EMP; MAEA recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 85% as determined by SDS-PAGE.
• Form/Format: The MAEA solution contains 20mM Tris-HCl buffer (pH 8.0), 1M Urea and 10% glycerol.; Sterile filtered colorless solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAVQESA AQLSMTLKVQ EYPTLKVPYE TLNKRFRAAQ KNIDRETSHV TMVVAELEKT LSGCPAVDSV VSLLDGVVEK LSVLKRKAVE SIQAEDESAK LCKRRIEHLK EHSSDQPAAA SVWKRKRMDR MMVEHLLRCG YYNTAVKLAR QSGIEDLVNI EMFLTAKEVE ESLERRETAT CLAWCHDNKS RLRKMKSCLE FSLRIQEFIE LIRQNKRLDA VRHARKHFSQ AEGSQLDEVR QAMGMLAFPP DTHISPYKDL LDPARWRMLI QQFRYDNYRL HQLGNNSVFT LTLQAGLSAI KTPQCYKEDG SSKSPDCPVC SRSLNKLAQP LPMAHCANSR LVCKISGDVM NENNPPMMLP NGYVYGYNSL LSIRQDDKVV CPRTKEVFHF SQAEKVYIM
• Sequence Length: 396

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for MAEA recombinant protein

Description: MAEA Human Recombinant (isoform 1) produced in E Coli is a single, non-glycosylated polypeptide chain containing 419 amino acids (1-396) and having a molecular mass of 47.7kDa.MAEA is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: MAEA is a 396aa widely expressed adhesion protein which has 5 alternatively spliced isoforms. MAEA holds one CTLH domain and one LisH domain. MAEA forms a complex with F-actin, which takes part in regulating actin distribution in erythroblasts and macrophages and is known to assist in cell division and nuclear architecture. MAEA is confined with condensed chromatin at prophase, nuclear spindle poles at metaphase and in the contractile ring throughout cytokinesis phase and telophase.

Product Categories/Family for MAEA recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 62953131
• NCBI GeneID: 10296
• NCBI Accession #: NP_001017405.1
• NCBI GenBank Nucleotide #: NM_001017405.2
• UniProt Accession #: Q7L5Y9; O95285; Q5JB54; Q6ZRD6; Q9BQ11; Q9H9V6; Q9H9Z4; Q9NW84
• Molecular Weight: 26,802 Da
• NCBI Official Full Name: macrophage erythroblast attacher isoform 1
• NCBI Official Synonym Full Names: macrophage erythroblast attacher
• NCBI Official Symbol: MAEA
• NCBI Official Synonym Symbols: EMP; EMLP; GID9; PIG5; HLC-10
• NCBI Protein Information: macrophage erythroblast attacher; GID complex subunit 9, FYV10 homolog; cell proliferation-inducing gene 5 protein; erythroblast macrophage protein; human lung cancer oncogene 10 protein; lung cancer-related protein 10
• UniProt Protein Name: Macrophage erythroblast attacher
• Protein Family: Macrophage erythroblast attacher
• UniProt Gene Name: MAEA
• UniProt Synonym Gene Names: EMP; HLC-10
• UniProt Entry Name: MAEA_HUMAN

NCBI Description

This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

MAEA: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Cell adhesion; Membrane protein, integral; Actin-binding

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: nucleoplasm; cytoskeleton; nuclear matrix; integral to plasma membrane; cytoplasm; contractile ring; spindle; nucleus

Molecular Function: actin binding

Biological Process: negative regulation of myeloid cell apoptosis; erythrocyte maturation; cell division; regulation of mitotic cell cycle; enucleate erythrocyte development; cytoskeleton organization and biogenesis; cell adhesion; cell cycle