LYVE1 recombinant protein

Recombinant Human LYVE1 Protein

Cat. Num. AAA8249422

• Gene Names: LYVE1; HAR; XLKD1; LYVE-1; CRSBP-1
• Reactivity: Human
• Applications: ELISA, Western Blot, SDS-Page
• Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Synonyms: LYVE1; Recombinant Human LYVE1 Protein; CRSBP1; HAR; XLKD1; Lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE-1; Cell surface retention sequence-binding protein 1; CRSBP-1; Extracellular link domain-containing protein 1; Hyaluronic acid receptor; LYVE1 recombinant protein

• Host: Human cells
• Reactivity: Human
• Purity/Purification: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 μM filtered solution of 20mM Tris-Citrate, 150mM NaCl, pH 7.0.
• Sequence: LVQGSLRAEE LSIQVSCRIM GITLVSKKAN QQLNFTEAKE ACRLLGLSLA GKDQVETALK ASFETCSYGW VGDGFVVISR ISPNPKCGKN GVGVLIRKVP VSRQFAAYCY NSSDTWTNSC IPEIITTKDP IFNTQTATQT TEFIVSDSTY SVASPYSTIP APTTTPPAPA STSIPRRKKL ICVTEVFMET STMSTETEPF VENKAAFKNE AAGFGGVPTV DHHHHHH
• Sequence Length: 322

• Applicable Applications for LYVE1 recombinant protein: ELISA (EIA), Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
• Endotoxin: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
• Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Preparation and Storage: Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C for 3 months.

Related Product Information for LYVE1 recombinant protein

Recombinant Human LYVE1 Protein is produced by our Mammalian expression system and the target gene encoding Leu20-Thr238 is expressed with a 6His tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 40549451
• NCBI GeneID: 10894
• NCBI Accession #: NP_006682.2
• NCBI GenBank Nucleotide #: NM_006691.3
• UniProt Accession #: Q9Y5Y7; Q8TC18; Q9UNF4
• NCBI Official Full Name: lymphatic vessel endothelial hyaluronic acid receptor 1
• NCBI Official Synonym Full Names: lymphatic vessel endothelial hyaluronan receptor 1
• NCBI Official Symbol: LYVE1
• NCBI Official Synonym Symbols: HAR; XLKD1; LYVE-1; CRSBP-1
• NCBI Protein Information: lymphatic vessel endothelial hyaluronic acid receptor 1
• UniProt Protein Name: Lymphatic vessel endothelial hyaluronic acid receptor 1
• Protein Family: Lymphatic vessel endothelial hyaluronic acid receptor
• UniProt Gene Name: LYVE1
• UniProt Synonym Gene Names: CRSBP1; HAR; XLKD1; LYVE-1; CRSBP-1
• UniProt Entry Name: LYVE1_HUMAN

NCBI Description

This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]

Uniprot Description

XLKD1: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: anatomical structure morphogenesis; cell motility; cell-matrix adhesion; hyaluronan catabolic process; response to wounding