Goat Lymphotactin ELISA Kit | LTN elisa kit

Goat Lymphotactin ELISA Kit

Cat. Num. AAA734427

• Gene Names: XCL1; LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a
• Reactivity: Goat
• Synonyms: Lymphotactin; Goat Lymphotactin ELISA Kit; LTN elisa kit

• Reactivity: Goat

• Samples: Human Serum And Cell Lysate
• Sensitivity: 0.45 ng/ml.
• Intra-assay Precision: The low, medium, high spiked sample was tested four times on one plate to assess intra-assay precision
• Inter-assay Precision: The low, medium, high spiked sample was tested in four separate assays to assess inter-assay precision.
• Preparation and Storage: Store all reagents at 2-8 degree C

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for LTN elisa kit

Intended Uses: This WRS ELISA kit is to be used for the determination of Tryptophanyl-tRNA synthetase (WRS) in human serum and cell lysate. This kit is intended for research use only!!Background/Introduction: WRS was the first aminoacyl-tRNA synthetase(ARS) for which cytokine activities have been propozed among ARSs. WRS is regulated not only at the level of posttranslational proteolysis, but also at the levels of transcription initiation and alternative splicing. It was shown that gene expression of WRS is regulated by interferon-gamma(IFN-gamma). At present time, major alternative form (mini-WRS) with reduced NH-terminus blocks EGF-induced angiogenesis by initiating apoptosis of endothelial cells. Interestingly, WRSinduced apoptosis similarly to AIMP1 induced apoptosis concentration dependent and is observed only at concentration of WRS>50 nM.

Product Categories/Family for LTN elisa kit

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 4506853
• NCBI GeneID: 6375
• NCBI Accession #: NP_002986.1
• NCBI GenBank Nucleotide #: NM_002995.2
• UniProt Accession #: P47992; Q52MA8
• Molecular Weight: 12,517 Da
• NCBI Official Full Name: lymphotactin
• NCBI Official Synonym Full Names: chemokine (C motif) ligand 1
• NCBI Official Symbol: XCL1
• NCBI Official Synonym Symbols: LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a
• NCBI Protein Information: lymphotactin; SCM-1-alpha; lymphotaxin; cytokine SCM-1; c motif chemokine 1; XC chemokine ligand 1; single cysteine motif 1a; small-inducible cytokine C1; small inducible cytokine subfamily C, member 1 (lymphotactin)
• UniProt Protein Name: Lymphotactin
• Protein Family: Lymphotactin
• UniProt Gene Name: XCL1
• UniProt Synonym Gene Names: LTN; SCYC1
• UniProt Entry Name: XCL1_HUMAN

NCBI Description

This gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Nov 2010]

Uniprot Description

XCL1: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. Belongs to the intercrine gamma family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: extracellular space; extracellular region

Molecular Function: protein homodimerization activity; chemokine activity; chemokine receptor binding

Biological Process: neutrophil chemotaxis; negative regulation of T-helper 1 type immune response; positive regulation of T cell mediated cytotoxicity; negative regulation of transcription factor activity; response to virus; positive regulation of T cell cytokine production; positive regulation of leukocyte chemotaxis; negative regulation of T cell cytokine production; signal transduction; positive regulation of interleukin-10 production; negative regulation of interleukin-2 production; cell-cell signaling; release of sequestered calcium ion into cytosol; negative regulation of interferon-gamma production; regulation of inflammatory response; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of transcription, DNA-dependent