E3 ubiquitin-protein ligase LRSAM1 (LRSAM1) Recombinant Protein | LRSAM1 recombinant protein

Recombinant Human E3 ubiquitin-protein ligase LRSAM1 (LRSAM1)

Cat. Num. AAA1327712

• Gene Names: LRSAM1; TAL; CMT2P; RIFLE
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: E3 ubiquitin-protein ligase LRSAM1 (LRSAM1); Recombinant Human E3 ubiquitin-protein ligase LRSAM1 (LRSAM1); LRSAM1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-723, Full length protein
• Sequence: MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLPRSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSLDASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTDRFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVKEEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSSMAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIETELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKSETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLLSQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVRPSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIYHSS
• Sequence Length: 723

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 53729361
• NCBI GeneID: 90678
• NCBI Accession #: NP_001005373.1
• NCBI GenBank Nucleotide #: NM_001005373.3
• UniProt Accession #: Q6UWE0; Q5VVV0; Q8NB40; Q96GT5; Q96MX5; Q96MZ7
• Molecular Weight: 35,069 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase LRSAM1 isoform 1
• NCBI Official Synonym Full Names: leucine rich repeat and sterile alpha motif containing 1
• NCBI Official Symbol: LRSAM1
• NCBI Official Synonym Symbols: TAL; CMT2P; RIFLE
• NCBI Protein Information: E3 ubiquitin-protein ligase LRSAM1
• UniProt Protein Name: E3 ubiquitin-protein ligase LRSAM1
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: LRSAM1
• UniProt Synonym Gene Names: hTAL

NCBI Description

This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jan 2012]

Uniprot Description

E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098).