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Mouse leucine-rich repeat kinase 1 ELISA Kit | LRRK1 elisa kit

Mouse Leucine-rich repeat serine/threonine-protein kinase 1, LRRK1 ELISA Kit

Gene Names
Lrrk1; AW319595; mKIAA1790; C230002E15Rik; D130026O16Rik
Reactivity
Mouse
Synonyms
leucine-rich repeat kinase 1; Mouse Leucine-rich repeat serine/threonine-protein kinase 1; LRRK1 ELISA Kit; Mouse Leucine-rich repeat serine/threonine-protein kinase 1 (LRRK1) ELISA kit; FLJ23119; FLJ27465; KIAA1790; RIPK6; Roco1; ; LRRK1 elisa kit
Ordering
For Research Use Only!
Reactivity
Mouse
Preparation and Storage
Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
225,470 Da
NCBI Official Full Name
leucine-rich repeat serine/threonine-protein kinase 1
NCBI Official Synonym Full Names
leucine-rich repeat kinase 1
NCBI Official Symbol
Lrrk1
NCBI Official Synonym Symbols
AW319595; mKIAA1790; C230002E15Rik; D130026O16Rik
NCBI Protein Information
leucine-rich repeat serine/threonine-protein kinase 1
UniProt Protein Name
Leucine-rich repeat serine/threonine-protein kinase 1
UniProt Gene Name
Lrrk1
UniProt Synonym Gene Names
Kiaa1790
UniProt Entry Name
LRRK1_MOUSE

Uniprot Description

LRRK1: a large multidomain protein kinase with a TKL-type kinase domain, multiple protein-protein interaction domains and a mitochondrial Rho domain (MIRO). Involved in the trafficking of epidermal growth factor (EGFR) from early to late endosomes. Forms a complex with activated EGFR via the adaptor protein Grb2. Subsequently, LRRK1 and EGFR are internalized and co-localized in early endosomes. LRRK1 is phosphorylated by EGFR, inhibiting its kinase activity. The reduction of kinase activity plays an important role in endosomal trafficking of the EGFR. Serves as a scaffold expediting the interaction of EGFR with the endosomal sorting complex required for efficient sorting of EGFR to the inner vesicles of multivesicular bodies. Plays a critical role in negative regulation of bone mass in part through modulating the c-Src signaling pathway in mice. Phosphorylation of c-Src at Tyr-527 is significantly elevated whereas at Tyr-416 is decreased in LRRK1 KO mouse osteoclasts.

Protein type: EC 2.7.11.1; Protein kinase, TKL; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); TKL group; LRRK family

Cellular Component: mitochondrion; cytoplasm; intracellular

Molecular Function: transferase activity; identical protein binding; protein serine/threonine kinase activity; protein binding; GTP binding; metal ion binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity

Biological Process: negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; small GTPase mediated signal transduction; phosphorylation; protein amino acid phosphorylation; bone resorption

Research Articles on LRRK1

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Product Notes

The Mouse LRRK1 lrrk1 (Catalog #AAA9328249) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328249 ELISA Kit recognizes Mouse LRRK1. It is sometimes possible for the material contained within the vial of "leucine-rich repeat kinase 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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