Low-density lipoprotein receptor-related protein 8 (Lrp8) Recombinant Protein | Lrp8 recombinant protein

Recombinant Mouse Low-density lipoprotein receptor-related protein 8 (Lrp8) , partial

• Gene Names: Lrp8; Lr8b; ApoER2; AA921429; AI848122; 4932703M08Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Low-density lipoprotein receptor-related protein 8 (Lrp8); Recombinant Mouse Low-density lipoprotein receptor-related protein 8 (Lrp8); partial; Lrp8 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 996

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Lrp8 recombinant protein

This gene encodes an apolipoprotein E receptor, a member of the low density lipoprotein receptor (LDLR) family. Apolipoprotein E is a small lipophilic plasma protein and a component of lipoproteins such as chylomicron remnants, very low density lipoprotein (VLDL), and high density lipoprotein (HDL). The apolipoprotein E receptor is involved in cellular recognition and internalization of these lipoproteins. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 755507868
• NCBI GeneID: 16975
• NCBI Accession #: XP_011238759.1
• NCBI GenBank Nucleotide #: XM_011240457.2
• UniProt Accession #: Q924X6; Q8CAK9; Q8CDF5; Q921B6
• Molecular Weight: – Da
• NCBI Official Full Name: low-density lipoprotein receptor-related protein 8 isoform X4
• NCBI Official Synonym Full Names: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
• NCBI Official Symbol: Lrp8
• NCBI Official Synonym Symbols: Lr8b; ApoER2; AA921429; AI848122; 4932703M08Rik
• NCBI Protein Information: low-density lipoprotein receptor-related protein 8
• UniProt Protein Name: Low-density lipoprotein receptor-related protein 8
• Protein Family: Low-density lipoprotein receptor-related protein
• UniProt Gene Name: Lrp8
• UniProt Synonym Gene Names: Apoer2; LRP-8

Uniprot Description

Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation (PubMed:12695510). May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (PubMed:18174160).