Lysophospholipid acyltransferase LPCAT4 (LPCAT4) Recombinant Protein | LPCAT4 recombinant protein
Recombinant Human Lysophospholipid acyltransferase LPCAT4 (LPCAT4)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]
Uniprot Description
AGPAT7: Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1- alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl- phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Protein type: Membrane protein, integral; EC 2.3.1.121; EC 2.3.1.n6; Transferase; EC 2.3.1.n7; Membrane protein, multi-pass; EC 2.3.1.67; EC 2.3.1.23
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; membrane
Molecular Function: 1-acylglycerol-3-phosphate O-acyltransferase activity; 1-acylglycerophosphocholine O-acyltransferase activity; 1-alkenylglycerophosphoethanolamine O-acyltransferase activity; 1-alkylglycerophosphocholine O-acetyltransferase activity; 2-acylglycerol-3-phosphate O-acyltransferase activity
Biological Process: phosphatidic acid biosynthetic process; phospholipid metabolic process; triacylglycerol biosynthetic process
Research Articles on LPCAT4
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Product Notes
The LPCAT4 lpcat4 (Catalog #AAA7019038) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-524aa; full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the LPCAT4 lpcat4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MSQGSPGDWA PLDPTPGPPA SPNPFVHELH LSRLQRVKFC LLGALLAPIR VLLAFIVLFL LWPFAWLQVA GLSEEQLQEP ITGWRKTVCH NGVLGLSRLL FFLLGFLRIR VRGQRASRLQ APVLVAAPHS TFFDPIVLLP CDLPKVVSRA ENLSVPVIGA LLRFNQAILV SRHDPASRRR VVEEVRRRAT SGGKWPQVLF FPEGTCSNKK ALLKFKPGAF IAGVPVQPVL IRYPNSLDTT SWAWRGPGVL KVLWLTASQP CSIVDVEFLP VYHPSPEESR DPTLYANNVQ RVMAQALGIP ATECEFVGSL PVIVVGRLKV ALEPQLWELG KVLRKAGLSA GYVDAGAEPG RSRMISQEEF ARQLQLSDPQ TVAGAFGYFQ QDTKGLVDFR DVALALAALD GGRSLEELTR LAFELFAEEQ AEGPNRLLYK DGFSTILHLL LGSPHPAATA LHAELCQAGS SQGLSLCQFQ NFSLHDPLYG KLFSTYLRPP HTSRGTSQTP NASSPGNPTA LANGTVQAPK QKGD. It is sometimes possible for the material contained within the vial of "Lysophospholipid acyltransferase LPCAT4 (LPCAT4), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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