Typical Testing Data/Standard Curve (for reference only)
Mouse lysyl oxidase-like 2 ELISA Kit | LOXL2 elisa kit
Mouse Lysyl oxidase homolog 2, LOXL2 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
Uniprot Description
LOXL2: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. Belongs to the lysyl oxidase family.
Protein type: Oxidoreductase; Secreted, signal peptide; Cell adhesion; Secreted; EC 1.4.3.13
Cellular Component: nucleoplasm; extracellular space; basement membrane; nucleus
Molecular Function: protein-lysine 6-oxidase activity; chromatin binding; transcription corepressor activity; methylated histone residue binding
Biological Process: collagen fibril organization; response to copper ion; endothelial cell proliferation; histone modification; protein modification process; epithelial to mesenchymal transition; endothelial cell migration; sprouting angiogenesis; negative regulation of transcription, DNA-dependent; protein amino acid deamination
Research Articles on LOXL2
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Product Notes
The Mouse LOXL2 loxl2 (Catalog #AAA909320) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA909320 ELISA Kit recognizes Mouse LOXL2. It is sometimes possible for the material contained within the vial of "lysyl oxidase-like 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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