Immunohistochemistry (IHC)
(Cl-peptide-+ Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Lamin A (cleaved-Asp230) antibody.)
anti-Mouse, Rat Lamin A Antibody | anti-LMNA antibody
Lamin A (Cleaved-Asp230) Antibody
IHC: 1:50~1:100
ELISA: 1:10000
Mouse: Asp230
Rat: Asp229
Immunohistochemistry (IHC)
(Cl-peptide-+ Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Lamin A (cleaved-Asp230) antibody.)
Immunohistochemistry (IHC)
(Cl-peptide-+ Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Lamin A (cleaved-Asp230) antibody.)
Western Blot (WB)
(Western blot analysis of extracts from HeLa cells, treated with etoposide (25muM, 1hour), using Lamin A (cleaved-Asp230) antibody.)
Western Blot (WB)
(Western blot analysis of extracts from HeLa cells, treated with etoposide (25muM, 1hour), using Lamin A (cleaved-Asp230) antibody.)
NCBI and Uniprot Product Information
NCBI Description
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
Uniprot Description
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:22431096, PubMed:10814726, PubMed:11799477, PubMed:18551513). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920).
Research Articles on LMNA
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Product Notes
The LMNA lmna (Catalog #AAA853553) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Lamin A (Cleaved-Asp230) Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Lamin A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA). WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:10000. Researchers should empirically determine the suitability of the LMNA lmna for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Lamin A, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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