Mouse lin-28 homolog B (C. elegans) ELISA Kit | LIN28B elisa kit
Mouse Protein lin-28 homolog B, LIN28B ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
LIN28B: Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. Interacts with ZCCHC11/TUT4. Might be negatively regulated by the microRNA let-7b. High expression in testis, fetal liver, placenta and in hepatocellular carcinoma (HCC). Isoform 1 is only detected in moderately and poorly differentiated HCC tissues and placenta. Isoform 2 is detected in fetal liver, non-tumor liver tissues, as well as well-differentiated tumor tissues. Belongs to the lin-28 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleolus; nucleus
Molecular Function: nucleic acid binding; DNA binding; zinc ion binding; RNA binding; metal ion binding
Biological Process: regulation of transcription, DNA-dependent; pre-microRNA processing; RNA-mediated gene silencing; RNA 3'-end processing
Research Articles on LIN28B
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Product Notes
The Mouse LIN28B lin28b (Catalog #AAA9337303) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337303 ELISA Kit recognizes Mouse LIN28B. It is sometimes possible for the material contained within the vial of "lin-28 homolog B (C. elegans), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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