CD118 recombinant protein

Recombinant Human CD118 protein, C-His Tag

Cat. Num. AAA1560571

• Gene Names: LIFR; SWS; SJS2; STWS; CD118; LIF-R
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CD118; Recombinant Human CD118 protein; C-His Tag; LIFR; CD118 recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Tag: C-His Tag
• Species: Homo sapiens (Human)
• Endotoxin Level: <1.0EU per ug of the protein as determined by the LAL method.
• Protein Construction: A DNA sequence encoding the human LIFR (Met1-Ser833) was fused with the C-terminal His Tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

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Product Categories/Family for CD118 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 189083786
• NCBI GeneID: 3977
• NCBI Accession #: NP_001121143.1
• NCBI GenBank Nucleotide #: NM_001127671.1
• UniProt Accession #: P42702; Q6LCD9
• Molecular Weight: 123,743 Da
• NCBI Official Full Name: leukemia inhibitory factor receptor
• NCBI Official Synonym Full Names: leukemia inhibitory factor receptor alpha
• NCBI Official Symbol: LIFR
• NCBI Official Synonym Symbols: SWS; SJS2; STWS; CD118; LIF-R
• NCBI Protein Information: leukemia inhibitory factor receptor; LIF receptor; CD118 antigen
• UniProt Protein Name: Leukemia inhibitory factor receptor
• UniProt Gene Name: LIFR
• UniProt Synonym Gene Names: LIF receptor; LIF-R
• UniProt Entry Name: LIFR_HUMAN

NCBI Description

This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

LIFR: Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells. Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS); also knowns as Schwartz-Jampel syndrome type 2 (SJS2). SWS is a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue. A chromosomal aberration involving LIFR is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1. Belongs to the type I cytokine receptor family. Type 2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 5p13-p12

Cellular Component: integral to plasma membrane; receptor complex

Molecular Function: oncostatin-M receptor activity; leukemia inhibitory factor receptor activity; growth factor binding; ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding

Biological Process: cell surface receptor linked signal transduction; response to cytokine stimulus; leukemia inhibitory factor signaling pathway; cytokine and chemokine mediated signaling pathway; positive regulation of cell proliferation

Disease: Stuve-wiedemann Syndrome