LGALS8 recombinant protein

Recombinant Human LGALS8 protein

Cat. Num. AAA1562587

• Gene Names: LGALS8; Gal-8; PCTA1; PCTA-1; Po66-CBP
• Purity: >90% as determined by SDS-PAGE
• Synonyms: LGALS8; Recombinant Human LGALS8 protein; Galectin-8; Gal-8; Po66 carbohydrate-binding protein; Po66-CBP; Prostate carcinoma tumor antigen 1; PCTA-1; LGALS8 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human LGALS8 (Met2-Trp317) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for LGALS8 recombinant protein

Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture.Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52.Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses.Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.

Product Categories/Family for LGALS8 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 42544185
• NCBI GeneID: 3964
• NCBI Accession #: NP_006490.3
• NCBI GenBank Nucleotide #: NM_006499.4
• UniProt Accession #: O00214; O15215; Q5T3P5; Q5T3Q4; Q8TEV1; Q96B92; Q9BXC8; Q9H584; Q9H585; Q9UEZ6; Q9UP32; Q9UP33
• Molecular Weight: 35,808 Da
• NCBI Official Full Name: galectin-8 isoform a
• NCBI Official Synonym Full Names: lectin, galactoside-binding, soluble, 8
• NCBI Official Symbol: LGALS8
• NCBI Official Synonym Symbols: Gal-8; PCTA1; PCTA-1; Po66-CBP
• NCBI Protein Information: galectin-8; galectin 8; galectin-8g; Po66 carbohydrate binding protein; po66 carbohydrate-binding protein; prostate carcinoma tumor antigen 1
• UniProt Protein Name: Galectin-8
• Protein Family: Galectin
• UniProt Gene Name: LGALS8
• UniProt Synonym Gene Names: Gal-8; Po66-CBP; PCTA-1
• UniProt Entry Name: LEG8_HUMAN

NCBI Description

This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

LGALS8: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: extracellular space; membrane; cytoplasm

Molecular Function: protein binding; carbohydrate binding

Biological Process: plasma cell differentiation; T cell costimulation