Galectin 1 Recombinant Protein | LGALS1 recombinant protein

Galectin 1 protein

Cat. Num. AAA5304036

• Gene Names: LGALS1; GBP; GAL1
• Purity: Galectin 1 protein was purified using a a proprietary chromatographic technique.
• Synonyms: Galectin 1; Galectin 1 protein; HBL protein; beta-galactoside-binding lectin L-14-I protein; Galectin-1 protein; Galectin-1; DKFZp686E23103 protein; S-Lac lectin 1 protein; Lectin galactoside-binding soluble 1 protein; Putative MAPK-activating protein PM12 protein; HPL protein; GBP protein; Galaptin protein; 14 kDa lectin protein; Lactose-binding lectin 1 protein; LGALS1 recombinant protein

• Host: Human
• Purity/Purification: Galectin 1 protein was purified using a a proprietary chromatographic technique.
• Form/Format: Sterile filtered and lyophilized from 20 mM Tris, pH 7.5
• Sequence Length: 135

• Protein Type: Recombinant
• Biological Significance: Galectin-1 belongs to growing family of evolutionary conserved animal lectins. Galectins consists of beta-galactoside binding lectins that contain homologous carbohydrate recognition domains. Galectin-1 has the ability to induce apoptosis of activated T-cells and T-leukaemia cell lines. Other activities include cell differentiation and inhibition activity of CD45 protein phosphatase activity. Galectin also binds beta-galactoside as well as CD45, CD3 and CD4.
• Endotoxin Levels: <0.1 ng/ug
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for LGALS1 recombinant protein

Purified recombinant Human Galectin 1 protein

Product Categories/Family for LGALS1 recombinant protein

Cell Cycle & Cell Death

NCBI and Uniprot Product Information

• NCBI GI #: 4504981
• NCBI GeneID: 3956
• NCBI Accession #: NP_002296.1
• NCBI GenBank Nucleotide #: NM_002305.3
• Molecular Weight: 14.5 kDa
• NCBI Official Full Name: galectin-1
• NCBI Official Synonym Full Names: lectin, galactoside-binding, soluble, 1
• NCBI Official Symbol: LGALS1
• NCBI Official Synonym Symbols: GBP; GAL1
• NCBI Protein Information: galectin-1
• UniProt Protein Name: Galectin-1
• UniProt Gene Name: LGALS1
• UniProt Synonym Gene Names: Gal-1; HLBP14
• UniProt Entry Name: LEG1_HUMAN

NCBI Description

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]

Uniprot Description

Galectin-1: May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Homodimer. Binds LGALS3BP. Interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Interacts with laminin (via poly-N- acetyllactosamine). Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion. Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; cell surface; cytoplasm; intracellular; nucleus

Molecular Function: protein binding; signal transducer activity; protein homodimerization activity; lactose binding; galactoside binding; laminin binding; glycoprotein binding

Biological Process: myoblast differentiation; regulation of apoptosis; response to drug; positive regulation of I-kappaB kinase/NF-kappaB cascade; plasma cell differentiation; apoptosis; T cell costimulation; positive regulation of erythrocyte aggregation; response to axon injury; signal transduction; multicellular organismal response to stress