SDS-PAGE
L-lactate dehydrogenase A chain Recombinant Protein | LDHA recombinant protein
Recombinant human L-lactate dehydrogenase A chain
SDS-PAGE
SDS-PAGE
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]
Uniprot Description
Catalytic activity: (S)-lactate + NAD+ = pyruvate + NADH.
Pathway: Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
Subunit structure: Homotetramer. Ref.22
Subcellular location: Cytoplasm.
Post-translational modification: ISGylated. Ref.15
Involvement in disease: Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [
MIM:612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue. Ref.13
Sequence similarities: Belongs to the LDH/MDH superfamily. LDH family.
Research Articles on LDHA
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Product Notes
The LDHA ldha (Catalog #AAA717238) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: KDQLIYNLLK EEQTPQNKIT VVGVGAVGMA CAISILMKDL ADELALVDVI EDKLKGEMMD LQHGSLFLRT PKIVSGKDYN VTANSKLVII TAGARQQEGE SRLNLVQRNV NIFKFIIPNV VKYSPNCKLL IVSNPVDILT YVAWKISGFP KNRVIGSGCN LDSARFRYLM GERLGVHPLS CHGWVLGEHG DSSVPVWSGM NVAGVSLKTL HPDLGTDKDK EQWKEVHKQV VESAYEVIKL KGYTSWAIGL SVADLAESIM KNLRRVHPVS TMIKGLYGIK DDVFLSVPCI LGQNGISDLV KVTLTSEEEA RLKKSADTL. It is sometimes possible for the material contained within the vial of "L-lactate dehydrogenase A chain, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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