Plastin-2 Recombinant Protein | PLSL recombinant protein

Recombinant Homo sapiens Plastin-2

Cat. Num. AAA9422370

• Gene Names: LCP1; LPL; CP64; PLS2; LC64P; HEL-S-37; L-PLASTIN
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Plastin-2; Recombinant Homo sapiens Plastin-2; L-plastin; LC64PLymphocyte cytosolic protein 1; LCP-1; PLSL recombinant protein

• Host: Yeast
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 2-627aa

• Tag Info: His-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for PLSL recombinant protein

Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.

NCBI and Uniprot Product Information

• NCBI GI #: 167614506
• NCBI GeneID: 3936
• NCBI Accession #: NP_002289.2
• NCBI GenBank Nucleotide #: NM_002298.4
• UniProt Accession #: P13796; Q5TBN4; B2R613; B4DUA0
• Molecular Weight: 72kD
• NCBI Official Full Name: plastin-2
• NCBI Official Synonym Full Names: lymphocyte cytosolic protein 1
• NCBI Official Symbol: LCP1
• NCBI Official Synonym Symbols: LPL; CP64; PLS2; LC64P; HEL-S-37; L-PLASTIN
• NCBI Protein Information: plastin-2
• UniProt Protein Name: Plastin-2
• Protein Family: Plastin
• UniProt Gene Name: LCP1
• UniProt Synonym Gene Names: PLS2; LCP-1

NCBI Description

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]

Uniprot Description

L-plastin: Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Monomer. Interacts with AIF1. Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T- lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 13q14.13

Cellular Component: actin cytoskeleton; actin filament; actin filament bundle; cytoplasm; cytosol; extracellular space; filopodium; focal adhesion; plasma membrane; podosome; ruffle; stress fiber

Molecular Function: actin filament binding; GTPase binding

Biological Process: actin crosslink formation; actin filament bundle formation; actin filament network formation; cell migration; extracellular matrix disassembly; regulation of intracellular protein transport; T cell activation during immune response