Lipocalin 2 Recombinant Protein | LCN2 recombinant protein

Lipocalin 2 protein

Cat. Num. AAA5303665

• Gene Names: LCN2; 24p3; MSFI; NGAL
• Purity: >95% by SDS-PAGE
• Synonyms: Lipocalin 2; Lipocalin 2 protein; Neutrophil gelatinase-associated lipocalin protein; Lipocalin-2 protein; MSFI protein; NGAL protein; Oncogene 24p3 protein; p25 protein; HNL protein; LCN2 protein; LCN-2 protein; LCN 2; 2 phospho D glycerate hydrolyase protein; Phosphopyruvate hydratase protein; Plasminogen binding protein; alpha enolase protein; C myc promoter binding protein; Enolase 1 protein; MBP1 protein; Non neural enolase protein; NNE protein; LCN2 recombinant protein

• Host: Yeast
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid in PBS, pH 7.4, with 50% Glycerol.
• Concentration: 3.0mg/ml (varies by lot)

• Application Notes: Suggested uses: as a Calibrator or Standard
• Product: Lipocalin 2 protein
• Species: Human
• Biological Significance: Lipocalin 2 is an iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Also known as NGAL protein or alpha enolase protein, it is a multifunctional enzyme that plays a part in various processes such as glycolysis, growth control, hypoxia tolerance and allergic responses.
• Grade: Recombinant
• Biohazard: Not hazardous. Use normal laboratory precautions and procedures when handling.
• Preparation and Storage: Upon receipt aliquot and store at -20°C to -80°C. Avoid repeat freeze-thaw cycles.

Product Categories/Family for LCN2 recombinant protein

Cell Cycle & Cell Death; Native Protein

NCBI and Uniprot Product Information

• NCBI GI #: 21619839
• NCBI GeneID: 3934
• NCBI Official Full Name: Lipocalin 2
• NCBI Official Synonym Full Names: lipocalin 2
• NCBI Official Symbol: LCN2
• NCBI Official Synonym Symbols: 24p3; MSFI; NGAL
• NCBI Protein Information: neutrophil gelatinase-associated lipocalin
• UniProt Protein Name: Neutrophil gelatinase-associated lipocalin
• Protein Family: Neutrophil gelatinase-associated lipocalin
• UniProt Gene Name: LCN2
• UniProt Synonym Gene Names: HNL; NGAL; NGAL
• UniProt Entry Name: NGAL_HUMAN

Uniprot Description

LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: extracellular space; extracellular region; cytosol

Molecular Function: protein homodimerization activity; protease binding; transporter activity; iron ion binding

Biological Process: response to drug; cellular response to nutrient levels; cellular iron ion homeostasis; response to virus; positive regulation of cell projection organization and biogenesis; siderophore transport; innate immune response; ion transport; response to herbicide; transmembrane transport