LIM and SH3 domain protein 1 Recombinant Protein | LASP1 recombinant protein

Recombinant Human LIM and SH3 domain protein 1

Cat. Num. AAA9421685

• Gene Names: LASP1; MLN50; Lasp-1
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: LIM and SH3 domain protein 1; Recombinant Human LIM and SH3 domain protein 1; Metastatic lymph node gene 50 protein; MLN 50; LASP1 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Partial of the Full Length of 1-261aa, 1-243aa

• Tag Info: GST-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for LASP1 recombinant protein

Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.

NCBI and Uniprot Product Information

• NCBI GI #: 410444379
• NCBI GeneID: 3927
• NCBI Accession #: NP_001258537.1
• NCBI GenBank Nucleotide #: NM_001271608.1
• UniProt Accession #: Q14847; Q96ED2; Q96IG0; B4DGQ0
• Molecular Weight: 55.2kD
• NCBI Official Full Name: LIM and SH3 domain protein 1 isoform b
• NCBI Official Synonym Full Names: LIM and SH3 protein 1
• NCBI Official Symbol: LASP1
• NCBI Official Synonym Symbols: MLN50; Lasp-1
• NCBI Protein Information: LIM and SH3 domain protein 1
• UniProt Protein Name: LIM and SH3 domain protein 1
• Protein Family: LIM and SH3 domain protein
• UniProt Gene Name: LASP1
• UniProt Synonym Gene Names: MLN50; LASP-1; MLN 50

NCBI Description

This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]

Uniprot Description

Lasp-1: a member of the LIM protein subfamily, characterized by a LIM motif and SH3 domain. Functions as an actin-binding protein, possibly in cytoskeletal organization.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cortical actin cytoskeleton; cytoplasm; focal adhesion

Molecular Function: cadherin binding; ion transmembrane transporter activity; protein binding; SH3/SH2 adaptor activity

Biological Process: ion transport