Minor capsid protein L2 (L2) Recombinant Protein | L2 recombinant protein

Recombinant Minor capsid protein L2 (L2), partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Minor capsid protein L2 (L2); Recombinant Minor capsid protein L2 (L2); partial; L2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 518

• Species: Bovinepapillomavirus type 3
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 23216982
• NCBI GeneID: 955389
• NCBI Accession #: NP_694450.1
• NCBI GenBank Nucleotide #: NC_004197.1
• UniProt Accession #: Q705F9; Q8BDD4
• Molecular Weight: 56,635 Da
• NCBI Official Full Name: putative minor capsid protein L2
• NCBI Official Symbol: L2
• NCBI Protein Information: putative minor capsid protein L2
• UniProt Protein Name: Minor capsid protein L2
• Protein Family: Minor capsid protein
• UniProt Gene Name: L2

Uniprot Description

Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, L2 escorts the genomic DNA into the nucleus by promoting escape from the endosomal compartments and traffic through the host Golgi network. Plays a role through its interaction with host dynein in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to host PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA.