Keratin Recombinant Protein | K1C14 recombinant protein
Recombinant Human Keratin, type I cytoskeletal 14
Generally, the shelf life of liquid form is 6 months at -20°C,-80°C. The shelf life of lyophilized form is 12 months at -20°C,-80°C.Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]
Uniprot Description
K14: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K5.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: cytoplasm; cytosol; intermediate filament; keratin filament; nucleus
Molecular Function: protein binding; structural constituent of cytoskeleton
Biological Process: aging; epidermis development; hair cycle; hemidesmosome assembly; intermediate filament bundle assembly; keratinization
Disease: Dermatopathia Pigmentosa Reticularis; Epidermolysis Bullosa Simplex, Autosomal Recessive 1; Epidermolysis Bullosa Simplex, Dowling-meara Type; Epidermolysis Bullosa Simplex, Generalized; Epidermolysis Bullosa Simplex, Localized; Naegeli Syndrome
Research Articles on K1C14
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Product Notes
The K1C14 krt14 (Catalog #AAA9422368) is a Recombinant Protein produced from Yeast and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is Full Length, 1-472aa. The Recombinant Human Keratin, type I cytoskeletal 14 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MTTCSRQFTS SSSMKGSCGI GGGIGGGSSR ISSVLAGGSC RAPSTYGGGL SVSSSRFSSG GACGLGGGYG G GFSSSSS SFGSGFGGGY GGGLGAGLGG GFGGGFAGGD GLLVGSEKVT MQNLNDRLAS YLDKVRALEE ANA DLEVK IRDWYQRQRP AEIKDYSPYF KTIEDLRNKI LTATVDNANV LLQIDNARLA ADDFRTKYET ELNLRMSVEA DINGLRRV LDELTLARAD LEMQIESLKE ELAYLKKNHE EEMNALRGQV GGDVNVEMDA APGVDLSRIL NEMRD QYE KMAEKNRKDA EEWFFTKTEE LNREVATNSE LVQSGKSEIS ELRRTMQNLE IELQSQLSMK ASLENSLEET KGRYCMQL AQIQEMIGSV EEQLAQLRCE MEQQNQEYKI LLDVKTRLEQ EIATYRRLLE GEDAHLSSSQ FSSGS QSS RDVTSSSRQI RTKVMDVHDG KVVSTHEQVL RTKN. It is sometimes possible for the material contained within the vial of "Keratin, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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