Histone-lysine N-methyltransferase MLL (Mll) Recombinant Protein | Mll recombinant protein
Recombinant Mouse Histone-lysine N-methyltransferase MLL (Mll) , partial
NCBI and Uniprot Product Information
Uniprot Description
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis (). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (PubMed:21113167).
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Product Notes
The Mll kmt2a (Catalog #AAA718009) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1010-1234; Partial. The amino acid sequence is listed below: ADKLPMTDKR VASLLKKAKA QLCKIEKSKS LKQTDQPKAQ GQESDSSETS VRGPRIKHVC RRAAVALGRK RAVFPDDMPT LSALPWEERE KILSSMGNDD KSSVAGSEDA EPLAPPIKPI KPVTRNKAPQ EPPVKKGRRS RRCGQCPGCQ VPEDCGICTN CLDKPKFGGR NIKKQCCKMR KCQNLQWMPS KASLQKQTKA VKKKEKKSKT TEKKESKEST AVKSP . It is sometimes possible for the material contained within the vial of "Histone-lysine N-methyltransferase MLL (Mll), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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