SDS-Page
(Recombinant Human NKG2-A/NKG2-B Type II Integral Membrane Protein Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.)
NKG2-A/NKG2-B Type II Integral Membrane Recombinant Protein | NKG2-A recombinant protein
Recombinant Human NKG2-A/NKG2-B Type II Integral Membrane Protein
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
SDS-Page
(Recombinant Human NKG2-A/NKG2-B Type II Integral Membrane Protein Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.)
SDS-Page
(Recombinant Human NKG2-A/NKG2-B Type II Integral Membrane Protein Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue.)
Background: NKG2-A/NKG2-B Type II Integral Membrane Protein contains 1 C-type lectin domain and belongs to the killercell lectin-like receptor family. The killer cell lectin-like receptor family is a group of transmembrane proteinspreferentially expressed in NK cells. Members of this proteins is characterized by the type II membraneorientation and the presence of a C-type lectin domain. NKG2 is expressed only in NK-cells, but not in T-cells orB-cells. It has been shown that NKG2 represents a family of related cDNA clones, designated NKG2A, NKG2B,NKG2C, and NKG2D, which encode type 2 integral membrane proteins (extracellular C-terminus) containing aC-type lectin domain. NKG2 plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NKcells and some cytotoxic T-cells. NKG2A and NKG2B have been given the designation CD159a in thenomenclature of CD antigens.
NCBI and Uniprot Product Information
NCBI Description
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]
Uniprot Description
NKG2A: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: protein binding; transmembrane receptor activity; carbohydrate binding
Biological Process: regulation of immune response; cell surface receptor linked signal transduction
Research Articles on NKG2-A
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Product Notes
The NKG2-A klrc1 (Catalog #AAA9140003) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: RHNNSSLNTR TQKARHCGHC PEEWITYSNS CYYIGKERRT WEESLLACTS KNSSLLSIDN EEEMKFLSII SPSSWIGVFR NSSHHPWVTM NGLAFKHEIK DSDNAELNCA VLQVNRLKSA QCGSSIIYHC KHKL. It is sometimes possible for the material contained within the vial of "NKG2-A/NKG2-B Type II Integral Membrane, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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