Kinesin-like protein Klp10A (Klp10A) Recombinant Protein | Klp10A recombinant protein

Recombinant Drosophila melanogaster Kinesin-like protein Klp10A (Klp10A), partial

• Gene Names: Klp10A; anon-WO03040301.142; CG1453; DmCG1453; DmelCG1453; DmKlp10A; DmKLP10A; KIF 2A; Kif2A; KIF2A/B/C; klp10A; KLP10a; KLP10A
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Kinesin-like protein Klp10A (Klp10A); Recombinant Drosophila melanogaster Kinesin-like protein Klp10A (Klp10A); partial; Klp10A recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 805

• Species: Drosophila melanogaster (Fruit fly)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 665390686
• NCBI GeneID: 32049
• NCBI Accession #: NP_001285109.1
• NCBI GenBank Nucleotide #: NM_001298180.1
• UniProt Accession #: Q960Z0
• Molecular Weight: 88,672 Da
• NCBI Official Full Name: Kinesin-like protein at 10A, isoform F
• NCBI Official Synonym Full Names: Kinesin-like protein at 10A
• NCBI Official Symbol: Klp10A
• NCBI Official Synonym Symbols: anon-WO03040301.142; CG1453; DmCG1453; DmelCG1453; DmKlp10A; DmKLP10A; KIF 2A; Kif2A; KIF2A/B/C; klp10A; KLP10a; KLP10A
• NCBI Protein Information: CG1453 gene product from transcript CG1453-RF
• UniProt Protein Name: Kinesin-like protein Klp10A
• Protein Family: Kinesin-like protein
• UniProt Gene Name: Klp10A

Uniprot Description

Required during anaphase to drive sister chromatid separation to promote flux by actively depolymerizing kinetochore microtubules at their pole-associated minus ends, thereby moving chromatids through a "poleward flux" (PubMed:14681690, PubMed:20946984, PubMed:24100293). Involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Klp98A targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cytokinesis, central spindle asymmetry is generated by enrichment of Patronin on the pIIb side which protects microtubules from depolymerization by Klp10A while unprotected microtubules on the pIIa side are disassembled by Klp10A, leading to the asymmetric delivery of Sara-expressing endosomes to the pIIa daughter cell (PubMed:26659188).