KLF6 recombinant protein

KLF6, 1-283aa, Human, His tag, E Coli

Cat. Num. AAA205587

• Gene Names: KLF6; GBF; ZF9; BCD1; CBA1; CPBP; PAC1; ST12; COPEB
• Applications: SDS-Page
• Purity: > 85% by SDS-PAGE
• Synonyms: KLF6; 1-283aa; Human; His tag; E Coli; Kruppel-like factor 6; B-cell-derived protein 1; BCD1; CBA1; COPEB; CPBP; Kruppel like factor 6; core promoter element binding protein; GBF; GC-rich binding factor; PAC1; Zf9; KLF6 recombinant protein

• Host: E Coli
• Purity/Purification: > 85% by SDS-PAGE
• Form/Format: Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol 1mM DTT
• Concentration: 1 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence Positions: 1-283aa
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMDVLPMC SIFQELQIVH ETGYFSALPS LEEYWQQTCL ELERYLQSEP CYVSASEIKF DSQEDLWTKI ILAREKKEES ELKISSSPPE DTLISPSFCY NLETNSLNSD VSSESSDSSE ELSPTAKFTS DPIGEVLVSS GKLSSSVTST PPSSPELSRE PSQLWGCVPG ELPSPGKVRS GTSGKPGDKG NGDASPDGRR RVHRCHFNGC RKVYTKSSHL KAHQRTHTGE KPYRCSWEGC EWRFARSDEL TRHFRKHTGA KPFKCSHCDR CFSRSDHLAL HMKRHL
• Sequence Length: 283

• Applicable Applications for KLF6 recombinant protein: SDS-PAGE
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 2-8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

SDS-Page

(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain)

Related Product Information for KLF6 recombinant protein

KLF6, also known as Krueppel-like factor 6, is a nuclear protein that has three zinc fingers. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. Recombinant human KLF6 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for KLF6 recombinant protein

Stem Cell

References

Narla G. et al. (2003) Am J Pathol. 162:1047-1052.; Narla G. et al. (2001) Science. 294:2563-2566;

NCBI and Uniprot Product Information

• NCBI GI #: 37655157
• NCBI GeneID: 1316
• NCBI Accession #: NP_001291
• NCBI GenBank Nucleotide #: NM_001300.5
• UniProt Accession #: Q99612; Q5VUT7; Q5VUT8; Q9BT79; B2RE86; B4DDN0; D3DRR1; F5H3M5
• Molecular Weight: 34.3 kDa (306aa) confirmed by MALDI-TOF
• NCBI Official Full Name: Krueppel-like factor 6 isoform A
• NCBI Official Synonym Full Names: Kruppel like factor 6
• NCBI Official Symbol: KLF6
• NCBI Official Synonym Symbols: GBF; ZF9; BCD1; CBA1; CPBP; PAC1; ST12; COPEB
• NCBI Protein Information: Krueppel-like factor 6
• UniProt Protein Name: Krueppel-like factor 6
• Protein Family: Krueppel-like factor
• UniProt Gene Name: KLF6
• UniProt Synonym Gene Names: BCD1; COPEB; CPBP; ST12

NCBI Description

This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]

Uniprot Description

Transcriptional activator (). Binds a GC box motif. Could play a role in B-cell growth and development.