Human Kruppel-like factor 11 ELISA Kit | KLF11 elisa kit
Human Krueppel-like factor 11, KLF11 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Uniprot Description
TIEG2: Transcription factor. Activates the epsilon- and gamma- globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. Defects in KLF11 are the cause of maturity-onset diabetes of the young type 7 (MODY7). MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 2p25
Cellular Component: nucleus
Molecular Function: metal ion binding; transcription factor activity
Biological Process: G1/S-specific transcription in mitotic cell cycle; transcription from RNA polymerase II promoter; negative regulation of cell proliferation; positive regulation of apoptosis; apoptosis; negative regulation of transcription from RNA polymerase II promoter
Disease: Maturity-onset Diabetes Of The Young, Type 7
Research Articles on KLF11
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Product Notes
The Human KLF11 klf11 (Catalog #AAA9337527) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337527 ELISA Kit recognizes Human KLF11. It is sometimes possible for the material contained within the vial of "Kruppel-like factor 11, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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