Putative killer cell immunoglobulin-like receptor like protein KIR3DP1 (KIR3DP1) Recombinant Protein | KIR3DP1 recombinant protein
Recombinant Human Putative killer cell immunoglobulin-like receptor like protein KIR3DP1 (KIR3DP1)
NCBI and Uniprot Product Information
NCBI Description
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. This gene is considered to be a pseudogene based on the absence of transcription and it lacks several functional domains compared to other killer cell immunoglobulin-like receptors. A rare haplotype, the result of a recombinantion event, has two copies of this gene, one of which may encode a secreted protein. (PMID: 15580659)[provided by RefSeq, Mar 2011]
Uniprot Description
MiscellaneousPubMed:15580659, identified a chromosomal rearrangement producing a recombinant gene composed of the promoter and first exon of KIR2DL5A fused to KIR3DP1 which was originally thought to be a pseudogene. This leads to the expression in 4.5 percent of a Spanish Caucasoid population of an mRNA which may encode a chimeric protein KIR2DL5A/KIR3DP1.
Research Articles on KIR3DP1
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Product Notes
The KIR3DP1 kir3dp1 (Catalog #AAA1057235) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 22-328, Full length protein. The amino acid sequence is listed below: HEGGQDKPFL SAWPSPVVSE GEHVALQCRS RLGFNEFSLS KEDGMPVPEL YNRVFRNTVF IGPVTPAHAG TYRCRGSHPH FLTGWSAPSN PLVIMVTGVH RKPSLLAHPG PLVKSEETVI LQCWSDVMFE HFLLHREGKF NDTLRLTGEL HDGVSKANFS IGRMTQDLAG TYRCYGSVPH SPYQLSAPSD PLDIVITGLC GKPSLSAQPR PMVKAGESVT LSCSSRSSYD IYHLSREGEA HELRFPAVPK VNGTFQANFP LGPATHGGTY RCFGSFRDSP YEWSDLSDPL LVSVTDSMKE KGKDVIL. It is sometimes possible for the material contained within the vial of "Putative killer cell immunoglobulin-like receptor like protein KIR3DP1 (KIR3DP1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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