Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) Recombinant Protein | KIR2DL4 recombinant protein

Recombinant Human Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4), partial

Cat. Num. AAA1328642

• Gene Names: KIR2DL4; G9P; CD158D; KIR103; KIR-2DL4; KIR103AS; KIR-103AS
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4); Recombinant Human Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4); partial; KIR2DL4 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 22-242
• Sequence: WAHVGGQDK PFCSAWPSAV VPQGGHVTLR CHYRRGFNIF TLYKKDGVPV PELYNRIFWN SFLISPVTPA HAGTYRCRGF HPHSPTEWSA PSNPLVIMVT GLYEKPSLTA RPGPTVRAGE NVTLSCSSQS SFDIYHLSRE GEAHELRLPA VPSINGTFQA DFPLGPATHG ETYRCFGSFH GSPYEWSDPS DPLPVSVTGN PSSSWPSPTE PSFKTGIARH LH
• Sequence Length: 221

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for KIR2DL4 recombinant protein

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the framework loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants.

NCBI and Uniprot Product Information

• NCBI GI #: 124107610
• NCBI GeneID: 3805
• NCBI Accession #: NP_001074239.1
• NCBI GenBank Nucleotide #: NM_001080770.1
• UniProt Accession #: Q99706; O14621; O14622; O14623; O14624; O43534; P78400; P78401; Q8N738; Q99559; Q99560; A8W795
• Molecular Weight: 24,917 Da
• NCBI Official Full Name: killer cell immunoglobulin-like receptor 2DL4 isoform c
• NCBI Official Synonym Full Names: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
• NCBI Official Symbol: KIR2DL4
• NCBI Official Synonym Symbols: G9P; CD158D; KIR103; KIR-2DL4; KIR103AS; KIR-103AS
• NCBI Protein Information: killer cell immunoglobulin-like receptor 2DL4
• UniProt Protein Name: Killer cell immunoglobulin-like receptor 2DL4
• Protein Family: Killer cell immunoglobulin-like receptor
• UniProt Gene Name: KIR2DL4
• UniProt Synonym Gene Names: CD158D; KIR103AS; KIR-103AS

NCBI Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. [provided by RefSeq, Jul 2016]

Uniprot Description

Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.