JMJD3 Blocking Peptide | KDM6B blocking peptide

JMJD3 Peptide

Cat. Num. AAA151937

• Gene Names: KDM6B; JMJD3
• Applications: Blocking (BL)
• Synonyms: JMJD3; JMJD3 Peptide; KIAA0346; Lysine-specific demethylase 6B; JmjC domain-containing protein 3; lysine (K)-specific demethylase 6B; KDM6B blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 1682

• Applicable Applications for KDM6B blocking peptide: Blocking (BL)
• Application Notes: JMJD3 peptide is used for blocking the activity of JMJD3 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 16 amino acids near the amino terminus of human JMJD3.
• Preparation and Storage: Store JMJD3 peptide at -20 degree C, stable for one year.

Western Blot (WB)

(Western blot analysis of JMJD3 in K562 cell lysate with JMJD3 antibody at 0.5 μg/mL in (A) the absence and (B) the presence of blocking peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 122937251
• NCBI GeneID: 23135
• NCBI Accession #: EAW90126
• NCBI GenBank Nucleotide #: NM_001080424.1
• UniProt Accession #: O15054; Q96G33; C9IZ40
• Molecular Weight: 180,702 Da
• NCBI Official Full Name: lysine-specific demethylase 6B
• NCBI Official Synonym Full Names: lysine (K)-specific demethylase 6B
• NCBI Official Symbol: KDM6B
• NCBI Official Synonym Symbols: JMJD3
• NCBI Protein Information: lysine-specific demethylase 6B; lysine demethylase 6B; jmjC domain-containing protein 3; jumonji domain-containing protein 3; jumonji domain containing 3, histone lysine demethylase
• UniProt Protein Name: Lysine-specific demethylase 6B
• Protein Family: Lysine-specific demethylase
• UniProt Gene Name: KDM6B
• UniProt Synonym Gene Names: JMJD3; KIAA0346
• UniProt Entry Name: KDM6B_HUMAN

Uniprot Description

JMJD3: Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Interacts with TLE1. Component of the MLL4 complex, at least composed of MLL4, ASH2L, RBBP5, WDR5, and KDM6B. By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Belongs to the UTX family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; dioxygenase activity; sequence-specific DNA binding; metal ion binding; beta-catenin binding

Biological Process: endothelial cell differentiation; establishment and/or maintenance of chromatin architecture; mesodermal cell differentiation; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; cardiac muscle cell differentiation