SDS-Page
(Recombinant JARID1C / KDM5C protein gel. JARID1C / KDM5C protein was run on a 8% SDS-PAGE gel and stained with Coomassie Blue. MW: 180 kDa Purity: > 87%)
JARID1C/KDM5C recombinant protein
Recombinant JARID1C/KDM5C protein
Shipping Temp: Dry Ice
SDS-Page
(Recombinant JARID1C / KDM5C protein gel. JARID1C / KDM5C protein was run on a 8% SDS-PAGE gel and stained with Coomassie Blue. MW: 180 kDa Purity: > 87%)
SDS-Page
(Recombinant JARID1C / KDM5C protein gel. JARID1C / KDM5C protein was run on a 8% SDS-PAGE gel and stained with Coomassie Blue. MW: 180 kDa Purity: > 87%)
Testing Data
(HTRF assay for JARID1C / KDM5C activity. 1 uM H3K4me3 peptide was incubated with JARID1C / KDM5C protein in reaction buffer for 1 hour at room temperature.H3K4me2 antibody was used to detect reaction product. )
Testing Data
(HTRF assay for JARID1C / KDM5C activity. 1 uM H3K4me3 peptide was incubated with JARID1C / KDM5C protein in reaction buffer for 1 hour at room temperature.H3K4me2 antibody was used to detect reaction product. )
Testing Data
(HTRF assay for JARID1C / KDM5C activity. 1 uM H3K4me3 peptide was incubated with JARID1C / KDM5C protein in reaction buffer for 1 hour at room temperature.H3K4me2 antibody was used to detect reaction product. )
Testing Data
(HTRF assay for JARID1C / KDM5C activity. 1 uM H3K4me3 peptide was incubated with JARID1C / KDM5C protein in reaction buffer for 1 hour at room temperature.H3K4me2 antibody was used to detect reaction product. )
Background: Lysine (K)-specific demethylase 5C (KDM5C), also known as Jumonji, AT rich interactive domain 1C (JARID1C), is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. It is a histone demethylase that specifically demethylates lysine 4 of histone H3 (H3K4), thereby playing a central role in defining the histone code. KDM5B demethylates trimethylated and dimethylated, but not monomethylated H3K4. It does not demethylate histone H3K9, H3K27, H3K36, H3K79 or H4K20. KDM5C participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and CoREST pAb at neuron-restrictive silencer elements. Mutations in KDM5C have been associated with X-linked mental retardation.
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Uniprot Description
JARID1C: Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Part of two distinct complexes, one containing E2F6, and the other containing REST. Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. Belongs to the JARID1 histone demethylase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.11.-; Oxidoreductase; Demethylase
Chromosomal Location of Human Ortholog: Xp11.22-p11.21
Cellular Component: nucleoplasm; nucleus
Molecular Function: histone demethylase activity (H3-K4 specific); DNA binding; zinc ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; rhythmic process; negative regulation of transcription, DNA-dependent
Disease: Mental Retardation, X-linked, Syndromic, Claes-jensen Type
Research Articles on JARID1C/KDM5C
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Product Notes
The JARID1C/KDM5C kdm5c (Catalog #AAA388148) is a Recombinant Protein produced from Baculovirus and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "JARID1C/KDM5C, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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