ER lumen protein retaining receptor 3 (KDELR3) Recombinant Protein | KDELR3 recombinant protein

Recombinant Human ER lumen protein retaining receptor 3 (KDELR3)

• Gene Names: KDELR3; ERD2L3
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: ER lumen protein retaining receptor 3 (KDELR3); Recombinant Human ER lumen protein retaining receptor 3 (KDELR3); Recombinant ER lumen protein retaining receptor 3 (KDELR3); ER lumen protein retaining receptor 3; KDEL endoplasmic reticulum protein retention receptor 3; KDEL receptor 3; KDELR3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-214
• Sequence: MNVFRILGDLSHLLAMILLLGKIWRSKCCKGISGKSQILFALVFTTRYLDLFTNFISIYNTVMKVVFLLCAYVTVYMIYGKFRKTFDSENDTFRLEFLLVPVIGLSFLENYSFTLLEILWTFSIYLESVAILPQLFMISKTGEAETITTHYLFFLGLYRALYLANWIRRYQTENFYDQIAVVSGVVQTIFYCDFFYLYVTKVLKGKKLSLPMPI
• Sequence Length: 214

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 6857802
• NCBI GeneID: 11015
• NCBI Accession #: NP_006846.1
• NCBI GenBank Nucleotide #: NM_006855.2
• UniProt Accession #: O43731; O95557; Q4V750; Q4V767; Q53FP4; Q53GK1; A8K7T7; B8ZZ26
• Molecular Weight: 25,027 Da
• NCBI Official Full Name: ER lumen protein retaining receptor 3 isoform a
• NCBI Official Synonym Full Names: KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
• NCBI Official Symbol: KDELR3
• NCBI Official Synonym Symbols: ERD2L3
• NCBI Protein Information: ER lumen protein retaining receptor 3; KDEL receptor 3; KDEL endoplasmic reticulum protein retention receptor 3
• UniProt Protein Name: ER lumen protein retaining receptor 3
• Protein Family: ER lumen protein-retaining receptor
• UniProt Gene Name: KDELR3
• UniProt Synonym Gene Names: KDEL receptor 3
• UniProt Entry Name: ERD23_HUMAN

NCBI Description

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified, and it encodes a protein highly homologous to KDELR1 and KDELR2 proteins. Two transcript variants of KDELR3 that arise by alternative splicing, and encode different isoforms of KDELR3 receptor, have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

KDELR3: Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L. Belongs to the ERD2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Endoplasmic reticulum; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: ER retention sequence binding

Biological Process: vesicle-mediated transport; protein transport; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response; protein retention in ER