Human potassium inwardly-rectifying channel, subfamily J, member 3 ELISA Kit | KCNJ3 elisa kit

Human G protein-activated inward rectifier potassium channel 1, KCNJ3 ELISA Kit

Gene Names

KCNJ3; KGA; GIRK1; KIR3.1

Reactivity

Human

Synonyms

potassium inwardly-rectifying channel; subfamily J; member 3; Human G protein-activated inward rectifier potassium channel 1; KCNJ3 ELISA Kit; Human G protein-activated inward rectifier potassium channel 1 (KCNJ3) ELISA kit; GIRK1; KGA; KIR3.1; G protein-activated inward rectifier potassium channel 1; inward rectifier K+ channel KIR3.1; potassium inwardly-rectifying channel J3; KCNJ3 elisa kit

Ordering
Cat. Num. AAA9322950 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Reactivity

Human

Preparation and Storage

Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

NCBI GI #

386781846

NCBI GeneID

3760

NCBI Accession #

NP_001247437.1

NCBI GenBank Nucleotide #

NM_001260508.1

UniProt Accession #

P48549; Q8TBI0; B4DEW7

Molecular Weight

56,603 Da

NCBI Official Full Name

G protein-activated inward rectifier potassium channel 1 isoform 2

NCBI Official Synonym Full Names

potassium inwardly-rectifying channel, subfamily J, member 3

NCBI Official Symbol

KCNJ3

NCBI Official Synonym Symbols

KGA; GIRK1; KIR3.1

NCBI Protein Information

G protein-activated inward rectifier potassium channel 1; GIRK-1; inward rectifier K+ channel KIR3.1; inward rectifier K(+) channel Kir3.1; potassium channel, inwardly rectifying subfamily J member 3; potassium inwardly-rectifying channel subfamily J member 3 splice variant 1e

UniProt Protein Name

G protein-activated inward rectifier potassium channel 1

Protein Family

G protein-activated inward rectifier potassium channel

UniProt Gene Name

KCNJ3

UniProt Synonym Gene Names

GIRK1; GIRK-1

UniProt Entry Name

KCNJ3_HUMAN

NCBI Description

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, May 2012]

Uniprot Description

GIRK1: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.

Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q24.1

Cellular Component: voltage-gated potassium channel complex; T-tubule; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity

Biological Process: synaptic transmission; potassium ion import; response to electrical stimulus; potassium ion transport

Research Articles on KCNJ3

1. we show that Kir3.1, in the absence of trafficking partner subunits, can exit the endoplasmic reticulum (ER) and reach the Golgi (though not the plasma membrane)

Similar Products

Product Notes

The Human KCNJ3 kcnj3 (Catalog #AAA9322950) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9322950 ELISA Kit recognizes Human KCNJ3. It is sometimes possible for the material contained within the vial of "potassium inwardly-rectifying channel, subfamily J, member 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

Loading...