ATP-sensitive inward rectifier potassium channel 1 (Kcnj1) Recombinant Protein | Kcnj1 recombinant protein
Recombinant Rat ATP-sensitive inward rectifier potassium channel 1 (Kcnj1)
NCBI and Uniprot Product Information
NCBI Description
potassium channel involved in K+ secretion in the renal distal nephron [RGD, Feb 2006]
Uniprot Description
Function: In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
Enzyme regulation: Inhibited by WNK3
By similarity.
Subunit structure: Interacts with SGK1 and SLC9A3R2/NHERF2
By similarity.
Subcellular location: Cell membrane; Multi-pass membrane protein. Note: Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane
By similarity.
Tissue specificity: Mainly in kidney (renal cortex, medulla and papilla). In the brain, found in the cortex and the hippocampus.
Post-translational modification: Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane
By similarity.
Sequence similarities: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily. [View classification]
Research Articles on Kcnj1
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Product Notes
The Kcnj1 kcnj1 (Catalog #AAA717525) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-391. The amino acid sequence is listed below: MGASERSVFR VLIRALTERM FKHLRRWFIT HIFGRSRQRA RLVSKEGRCN IEFGNVDAQS RFIFFVDIWT TVLDLKWRYK MTVFITAFLG SWFLFGLLWY VVAYVHKDLP EFYPPDNRTP CVENINGMTS AFLFSLETQV TIGYGFRFVT EQCATAIFLL IFQSILGVII NSFMCGAILA KISRPKKRAK TITFSKNAVI SKRGGKLCLL IRVANLRKSL LIGSHIYGKL LKTTITPEGE TIILDQTNIN FVVDAGNENL FFISPLTIYH IIDHNSPFFH MAAETLSQQD FELVVFLDGT VESTSATCQV RTSYVPEEVL WGYRFVPIVS KTKEGKYRVD FHNFGKTVEV ETPHCAMCLY NEKDARARMK RGYDNPNFVL SEVDETDDTQ M. It is sometimes possible for the material contained within the vial of "ATP-sensitive inward rectifier potassium channel 1 (Kcnj1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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