Human potassium inwardly-rectifying channel, subfamily J, member 1 ELISA Kit | KCNJ1 elisa kit
Human ATP-sensitive inward rectifier potassium channel 1, KCNJ1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
ROMK: an inward rectifier-type potassium channel protein. Probably plays a major role in potassium homeostasis in the kidney. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The channel is activated by internal ATP and can be blocked by external barium. High levels of expression in the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. Three alternatively spliced isoforms have been described.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium
Chromosomal Location of Human Ortholog: 11q24
Cellular Component: voltage-gated potassium channel complex; plasma membrane
Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; ATP-activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; ATP binding
Biological Process: synaptic transmission; potassium ion import; tissue homeostasis; excretion; kidney development; potassium ion transport; post-embryonic development
Disease: Bartter Syndrome, Antenatal, Type 2
Research Articles on KCNJ1
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Product Notes
The Human KCNJ1 kcnj1 (Catalog #AAA9335530) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9335530 ELISA Kit recognizes Human KCNJ1. It is sometimes possible for the material contained within the vial of "potassium inwardly-rectifying channel, subfamily J, member 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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