Potassium voltage-gated channel subfamily H member 2 (KCNH2) Recombinant Protein | KCNH2 recombinant protein
Recombinant Guinea pig Potassium voltage-gated channel subfamily H member 2 (KCNH2)
NCBI and Uniprot Product Information
Uniprot Description
Function: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr)
By similarity.
Subunit structure: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH6/ERG2, KCNH7/ERG3, KCNE1 and KCNE2. Interacts with ALG10B
By similarity. Interacts with CANX
By similarity.
Subcellular location: Membrane; Multi-pass membrane protein.
Tissue specificity: Highly expressed in heart and brain.
Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similarities: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily. [View classification]
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Product Notes
The Potassium voltage-gated channel subfamily H member 2 (KCNH2) kcnh2 (Catalog #AAA1209238) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-162. The amino acid sequence is listed below: AVWDWLILLL VIYTAVFTPY SAAFLLKEPE EDAQTADCGY ACQPLAVVDL IVDIMFIVDI LINFRTTYVN ANEEVVSHPG RIAVHYFKGW FLIDMVAAIP FDLLIFGSGS EELIGLLKTA RLLRLVRVAR KLDRYSEYGA AVLFLLMCTF ALIAHWLACI WY. It is sometimes possible for the material contained within the vial of "Potassium voltage-gated channel subfamily H member 2 (KCNH2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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