Junctophilin 3 (JPH3) Recombinant Protein | JPH3 recombinant protein

Recombinant Junctophilin 3 (JPH3)

Cat. Num. AAA2086933

• Gene Names: Jph3; Jp3; JP-3
• Applications: SDS-Page, Western Blot
• Purity: > 90%
• Synonyms: Junctophilin 3 (JPH3); Recombinant Junctophilin 3 (JPH3); CAGL237; HDL2; JP-3; JP3; TNRC22; Trinucleotide Repeat Containing 22; JPH3 recombinant protein

• Host: E Coli
• Purity/Purification: > 90%
• Form/Format: Freeze-dried powder
• Sequence Length: 744

• Applicable Applications for JPH3 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Fragment: Met1~Leu266
• Tag: N-terminal His-tag
• Buffer Formulation: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Source Note: Prokaryotic expression
• Organism Species: Mouse
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Isoelectric Point: 9.6
• Subcellular Location: Cell Membrane; Peripheral Membrane Protein. Endoplasmic Reticulum Membrane; Single-pass Type Iv Membrane Protei
• Usage: Reconstitute in sterile ddH2O.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

Product Categories/Family for JPH3 recombinant protein

Recombinant Protein

NCBI and Uniprot Product Information

• NCBI GI #: 10181142
• NCBI GeneID: 57340
• NCBI Accession #: NP_065630.1
• NCBI GenBank Nucleotide #: NM_020605.3
• UniProt Accession #: Q9ET77; Q3ZAS3; Q8BNM7; Q9EQZ2
• Molecular Weight: 32.1kDa
• NCBI Official Full Name: junctophilin-3
• NCBI Official Synonym Full Names: junctophilin 3
• NCBI Official Symbol: Jph3
• NCBI Official Synonym Symbols: Jp3; JP-3
• NCBI Protein Information: junctophilin-3
• UniProt Protein Name: Junctophilin-3
• Protein Family: Junctophilin
• UniProt Gene Name: Jph3
• UniProt Synonym Gene Names: Jp3; JP-3

Uniprot Description

JPH3: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. Defects in JPH3 are the cause of Huntington disease-like type 2 (HDL2). Huntington disease (HD) is a neurodegenerative disorder resulting primarily from the loss of medium spiny projection neurons in the striatum, especially in the caudate nucleus, and, to a lesser extent, atrophy of mesencephalic and cortical structures. The typical clinical picture of HD combines familial adult onset chorea and subcortical dementia that usually begin during the fourth decade of life. Belongs to the junctophilin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8|8 E1

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; junctional membrane complex; plasma membrane

Molecular Function: calcium-release channel activity

Biological Process: learning; locomotion; memory; neuromuscular process controlling balance; regulation of neuronal synaptic plasticity