Human intersectin 1 (SH3 domain protein) ELISA Kit | ITSN1 elisa kit

Human Intersectin-1, ITSN1 ELISA Kit

Cat. Num. AAA9331518

• Gene Names: ITSN1; ITSN; SH3D1A; SH3P17
• Reactivity: Human
• Synonyms: intersectin 1 (SH3 domain protein); Human Intersectin-1; ITSN1 ELISA Kit; Human Intersectin-1 (ITSN1) ELISA kit; ITSN; MGC134948; MGC134949; SH3D1A; SH3P17; SH3 domain protein-1A; Src homology 3 domain-containing protein; human intersectin-SH3 domain-containing protein SH3P17; intersectin 1; intersectin 1 short fo; ITSN1 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 47717125
• NCBI GeneID: 6453
• NCBI Accession #: NP_001001132.1
• NCBI GenBank Nucleotide #: NM_001001132.1
• UniProt Accession #: Q15811; A7Y322; A8CTX8; A8CTY3; A8CTY7; A8D7D0; A8DCP3; B4DTM2; E7ERJ1; E9PE44; E9PG01; E9PHV2
• Molecular Weight: 195,422 Da
• NCBI Official Full Name: intersectin-1 isoform ITSN-s
• NCBI Official Synonym Full Names: intersectin 1 (SH3 domain protein)
• NCBI Official Symbol: ITSN1
• NCBI Official Synonym Symbols: ITSN; SH3D1A; SH3P17
• NCBI Protein Information: intersectin-1; intersectin short variant 12; SH3 domain-containing protein 1A; intersectin 1 short form variant 3; intersectin 1 short form variant, 11; Src homology 3 domain-containing protein; human intersectin-SH3 domain-containing protein SH3P17
• UniProt Protein Name: Intersectin-1
• Protein Family: Intersectin
• UniProt Gene Name: ITSN1
• UniProt Synonym Gene Names: ITSN; SH3D1A
• UniProt Entry Name: ITSN1_HUMAN

NCBI Description

The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008]

Uniprot Description

ITSN1: Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; GEFs, Rac/Rho; GEFs; Calcium-binding

Chromosomal Location of Human Ortholog: 21q22.1-q22.2

Cellular Component: neuron projection; lamellipodium; endocytic vesicle; plasma membrane; synapse; coated pit; cell junction; cytosol

Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; guanyl-nucleotide exchange factor activity; kinase activator activity; calcium ion binding; protein complex scaffold

Biological Process: positive regulation of protein kinase B signaling cascade; axon guidance; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; synaptic vesicle endocytosis; ephrin receptor signaling pathway; negative regulation of neuron apoptosis; positive regulation of phosphorylation; positive regulation of GTPase activity