Human inositol 1, 4, 5-triphosphate receptor, type 3 ELISA Kit | ITPR3 elisa kit

Human Inositol 1, 4, 5-trisphosphate receptor type 3, ITPR3 ELISA Kit

Cat. Num. AAA9331248

• Gene Names: ITPR3; IP3R; IP3R3
• Reactivity: Human
• Synonyms: inositol 1; 4; 5-triphosphate receptor; type 3; Human Inositol 1; 5-trisphosphate receptor type 3; ITPR3 ELISA Kit; 5-trisphosphate receptor type 3 (ITPR3) ELISA kit; FLJ36205; IP3R; IP3R3; Inositol 1; 5-trisphosphate receptor type 3 (Type 3 inositol 1; 5-trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3) ; ITPR3 elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Samples: Serum, Plasma and Tissue Homogenate
• Detection Range: 0.25ng/ml-8ng/ml.
• Sensitivity: 0.1ng/ml.
• Assay Type: Sandwich
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for ITPR3 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of ITPR3 (hereafter termed this analyte) in undiluted original Human serum, plasma and tissue homogenate samples.

NCBI and Uniprot Product Information

• NCBI GI #: 153945846
• NCBI GeneID: 3710
• NCBI Accession #: NP_002215.2
• NCBI GenBank Nucleotide #: NM_002224.3
• UniProt Accession #: Q14573; Q14649; Q5TAQ2
• Molecular Weight: 304,106 Da
• NCBI Official Full Name: inositol 1,4,5-trisphosphate receptor type 3
• NCBI Official Synonym Full Names: inositol 1,4,5-trisphosphate receptor, type 3
• NCBI Official Symbol: ITPR3
• NCBI Official Synonym Symbols: IP3R; IP3R3
• NCBI Protein Information: inositol 1,4,5-trisphosphate receptor type 3; insP3R3; IP3 receptor; type 3 InsP3 receptor; inositol 1,4,5-triphosphate receptor, type 3
• UniProt Protein Name: Inositol 1,4,5-trisphosphate receptor type 3
• Protein Family: Inositol 1,4,5-trisphosphate receptor
• UniProt Gene Name: ITPR3
• UniProt Synonym Gene Names: IP3R 3; InsP3R3; Type 3 InsP3 receptor
• UniProt Entry Name: ITPR3_HUMAN

NCBI Description

This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]

Uniprot Description

IP3R3: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Expressed in intestinal crypt and villus epithelial cells. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues. Belongs to the InsP3 receptor family.

Protein type: Channel, ligand-gated; Membrane protein, integral; Channel, calcium; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: nuclear outer membrane; endoplasmic reticulum membrane; endoplasmic reticulum; integral to plasma membrane; nucleoplasm; membrane; cell soma; apical part of cell; cytoplasm; nucleolus; plasma membrane; brush border; myelin sheath; receptor complex

Molecular Function: protein binding; inositol 1,3,4,5 tetrakisphosphate binding; inositol hexakisphosphate binding; intracellular ligand-gated calcium channel activity; phosphoinositide binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity

Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; inositol phosphate-mediated signaling; sensory perception of umami taste; sensory perception of sweet taste; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; protein heterooligomerization; signal transduction; memory; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; phospholipase C activation; energy reserve metabolic process; innate immune response; sensory perception of bitter taste; blood coagulation; response to calcium ion; vascular endothelial growth factor receptor signaling pathway; regulation of insulin secretion; protein homooligomerization

Disease: Diabetes Mellitus, Insulin-dependent