Mouse inosine triphosphatase (nucleoside triphosphate pyrophosphatase) ELISA Kit | ITPA elisa kit
Mouse Inosine triphosphate pyrophosphatase, ITPA ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
ITPA: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPA are the cause of inosine triphosphate pyrophosphohydrolase deficiency (ITPAD). It is a common inherited trait characterized by the abnormal accumulation of inosine triphosphate (ITP) in erythrocytes and also leukocytes and fibroblasts. The pathological consequences of ITPA deficiency, if any, are unknown. However, it might have pharmacogenomic implications and be related to increased drug toxicity of purine analog drugs. Three different human populations have been reported with respect to their ITPase activity: high, mean (25% of high) and low activity. The variant Thr-32 is associated with complete loss of enzyme activity, may be by altering the local secondary structure of the protein. Heterozygotes for this polymorphism have 22.5% of the control activity: this is consistent with a dimeric structure of the enzyme. Belongs to the HAM1 NTPase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleotide Metabolism - pyrimidine; Hydrolase; EC 3.6.1.19; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - purine
Cellular Component: cytoplasm
Molecular Function: hydrolase activity; metal ion binding; nucleotide binding; nucleoside-triphosphate diphosphatase activity
Biological Process: nucleoside triphosphate catabolic process; ITP catabolic process; nucleotide metabolic process; chromosome organization and biogenesis
Research Articles on ITPA
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Product Notes
The Mouse ITPA itpa (Catalog #AAA9333175) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9333175 ELISA Kit recognizes Mouse ITPA. It is sometimes possible for the material contained within the vial of "inosine triphosphatase (nucleoside triphosphate pyrophosphatase), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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