Integrin Alpha D (ITGaD) Recombinant Protein | ITGaD recombinant protein

Recombinant Integrin Alpha D (ITGaD)

Cat. Num. AAA2018702

• Gene Names: ITGAD; ADB2; CD11D
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Integrin Alpha D (ITGaD); Recombinant Integrin Alpha D (ITGaD); ITGaD recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.; MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- FD VSYKATLGDR MLMRASASSE NNKASSSKAT FQLELPVKYA VYTMISRQEE STKYFNFATS DEKKMKEAEH RYRVNNLSQR DLAISINFWV PVLLNGVAVW DVVMEAPSQS LPCVSERKPP QHSDFLTQIS RSPMLDCSIA DCLQFRCDVP SFSVQEELDF TLKGNLSFGW VRETLQKKVL VVSVAEITFD TSVYSQLPGQ EAFMRAQMEM VLEEDEVYN
• Sequence Length: 1161

• Applicable Applications for ITGaD recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Homo sapiens (Human)
• Expression System: Prokaryotic expression
• Residues: Phe879~Asn1099 (Accession # Q13349) with two N-terminal Tags, His-tag and T7-tag
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 62548866
• NCBI GeneID: 3681
• NCBI Accession #: NP_005344.2
• NCBI GenBank Nucleotide #: NM_005353.2
• UniProt Accession #: Q13349; Q15575; Q15576
• Molecular Weight: 29.0kDa
• NCBI Official Full Name: integrin alpha-D
• NCBI Official Synonym Full Names: integrin, alpha D
• NCBI Official Symbol: ITGAD
• NCBI Official Synonym Symbols: ADB2; CD11D
• NCBI Protein Information: integrin alpha-D; leukointegrin alpha D; CD11 antigen-like family member D
• UniProt Protein Name: Integrin alpha-D
• Protein Family: Integrin
• UniProt Gene Name: ITGAD
• UniProt Entry Name: ITAD_HUMAN

Uniprot Description

ITGAD: Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood- borne pathogens, particulate matter, and senescent erythrocytes from the blood. Belongs to the integrin alpha chain family.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cell surface; plasma membrane; integrin complex

Molecular Function: metal ion binding

Biological Process: integrin-mediated signaling pathway; heterotypic cell-cell adhesion; extracellular matrix organization and biogenesis; activated T cell proliferation; immune response