Integrin alpha-8 (Itga8) Recombinant Protein | Itga8 recombinant protein

Recombinant Mouse Integrin alpha-8 (Itga8) , partial

• Gene Names: Itga8; AI447669
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Integrin alpha-8 (Itga8); Recombinant Mouse Integrin alpha-8 (Itga8); partial; Itga8 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 286

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 47717127
• NCBI GeneID: 241226
• NCBI Accession #: NP_001001309.1
• NCBI GenBank Nucleotide #: NM_001001309.3
• UniProt Accession #: A2ARA8; O70304; Q3UXV8; Q8BRG3; Q8C0H7
• Molecular Weight: 31,011 Da
• NCBI Official Full Name: integrin alpha-8 preproprotein
• NCBI Official Synonym Full Names: integrin alpha 8
• NCBI Official Symbol: Itga8
• NCBI Official Synonym Symbols: AI447669
• NCBI Protein Information: integrin alpha-8
• UniProt Protein Name: Integrin alpha-8
• Protein Family: Integrin
• UniProt Gene Name: Itga8

NCBI Description

This gene encodes a member of the integrin family of cell surface proteins that mediate cellular interactions with the extracellular matrix and other cells. The encoded protein undergoes proteolytic processing to generate the disulfide-linked heterodimeric alpha subunit which, in turn associates with a beta subunit to form the functional integrin receptor. Mice lacking the encoded protein mostly die after birth due to kidney defects, but some of animals that survive exhibit defects in the sensory hair cells of the inner ear. [provided by RefSeq, Aug 2016]

Uniprot Description

Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.