Human integrin, alpha 8 ELISA Kit | ITGA8 elisa kit

Human integrin, alpha 8, ITGA8 ELISA Kit

Cat. Num. AAA9332917

• Reactivity: Human
• Synonyms: integrin; alpha 8; Human integrin; ITGA8 ELISA Kit; alpha 8 (ITGA8) ELISA kit; ITGA8 elisa kit

• Reactivity: Human

• Samples: Human Body Fluids And Tissue Homogenates
• Assay Type: Quantitative Sandwich
• Detection Range: 0.625ng/ml-20ng/ml
• Sensitivity: 1.0ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for ITGA8 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only! This kit is intended to be used for determine the level of ITGA6 (hereafter termed "analyte") in undiluted original Human body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 612407851
• NCBI GeneID: 8516
• NCBI Accession #: NP_003629.2
• NCBI GenBank Nucleotide #: NM_003638.2
• UniProt Accession #: P53708; Q5VX94; B0YJ31
• Molecular Weight: 117,474 Da
• NCBI Official Full Name: integrin alpha-8 Isoform 1 preproprotein
• NCBI Official Synonym Full Names: integrin, alpha 8
• NCBI Official Symbol: ITGA8
• NCBI Protein Information: integrin alpha-8
• UniProt Protein Name: Integrin alpha-8
• Protein Family: Integrin
• UniProt Gene Name: ITGA8
• UniProt Entry Name: ITA8_HUMAN

NCBI Description

Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]

Uniprot Description

ITGA8: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. Belongs to the integrin alpha chain family.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: cell surface; focal adhesion; endoplasmic reticulum; apical part of cell; postsynaptic density; plasma membrane; perikaryon; integrin complex

Molecular Function: metal ion binding

Biological Process: integrin-mediated signaling pathway; inner ear morphogenesis; extracellular matrix organization and biogenesis; cell-matrix adhesion; positive regulation of transforming growth factor beta receptor signaling pathway; mesodermal cell differentiation; memory; smooth muscle development; cell-cell adhesion; establishment of protein localization; cell projection organization and biogenesis; brain development; kidney development; metanephros development

Disease: Renal Hypodysplasia/aplasia 1