Innexin-19 (inx-19) Recombinant Protein | inx-19 recombinant protein
Recombinant Innexin-19 (inx-19)
NCBI and Uniprot Product Information
Uniprot Description
Function: Structural component of the gap junctions that specifically coordinates left-right asymmetry in the developing nervous system. Acts by forming gap junction network linking embryonic neurons and providing electrical coupling between cells, leading to promote or inhibit AWC signaling. Required for the left and right AWC olfactory neurons to establish asymmetric patterns of gene expression during embryogenesis. Acts autonomously. Ref.3
Subcellular location: Cell membrane; Multi-pass membrane protein. Cell junction › gap junction. Note: Specifically present at the transient gap junctions formed between the cell bodies of embryonic neurons. Excluded from axons and dendrites. Ref.3
Tissue specificity: Specifically expressed in sensory neurons and interneurons in the head and tail. Expressed in neurons AWC, ASH, AFD, ASI, ADL, ASK, BAG, AWB, and ADF (head sensory neurons); ADA, AIZ, RIC, AIY, and AIM (head interneurons); PHA and PHB (tail sensory neurons); and PVC and PVQ (tail interneurons). Ref.3
Developmental stage: Expression begins about halfway through embryogenesis. Expressed at higher level in late embryos and in L1 larvae, and fades thereafter. In adults, a weak expression is maintained in several neurons, including ASH but not AWC. Ref.3
Sequence similarities: Belongs to the pannexin family.
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Product Notes
The inx-19 inx-19 (Catalog #AAA1077526) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-454. The amino acid sequence is listed below: MWRTPASTGP LRQDRQMFFH ATLARSFINA LSVRGDDDAV DRLNYYYTPL ILAVCCLVIS AKQYGGTPIE CWVNPHSRES MEEYIESYCW IQNTYWIPMY ENVPDDHTAR EEKQIGYYQW VPFILIAEAL MFSLPCIFWR LCSFQSGLNI QTLINAACDG QALLDASDRQ KAVEAITTNF VDNLDLQSPN GRIRARGWIA RIKFSRFLSG QCLSILHSFT KLLYSMNVVA QFLILNACLK SSDFLFFGFQ VLNDIWAGRP WTETGHFPRV TLCDFEVRYL ANLNRYTVQC ALLINIINEK VFAFLWCWYM ILAIITTCSF IYWIANSFIH SEKVDYVMKF IQIAESSEFK KLQKFEKDAT VERLYTVIAF APHLLDTFVS DFLKSDGVLM LRMISNHAGD MIVVQLVRNL WQEFRERNWR EFEEHEEMKD VEMRRIHGGE RIVISNPGQT KSFL. It is sometimes possible for the material contained within the vial of "Innexin-19 (inx-19), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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