Mouse inversin ELISA Kit | INVS elisa kit
Mouse Inversin, INVS ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
INVS: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis. Defects in INVS are the cause of nephronophthisis type 2 (NPHP2); also known as infantile nephronophthisis. NPHP2 is an autosomal recessive disorder resulting in end-stage renal disease. It is characterized by early onset and rapid progression. Phenotypic manifestations include enlarged kidneys, chronic tubulo-interstitial nephritis, anemia, hyperkalemic metabolic acidosis. Some patients also display situs inversus. Pathologically, it differs from later-onset nephronophthisis by the absence of medullary cysts and thickened tubular basement membranes and by the presence of cortical microcysts. 3 isoforms of the human protein are produced by alternative splicing.
Cellular Component: microtubule; cytoskeleton; membrane; cytoplasm; nucleus
Molecular Function: calmodulin binding; protein binding
Biological Process: Wnt receptor signaling pathway; multicellular organismal development; pancreas development; organ development; kidney development; post-embryonic development
Research Articles on INVS
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Product Notes
The Mouse INVS invs (Catalog #AAA9334185) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334185 ELISA Kit recognizes Mouse INVS. It is sometimes possible for the material contained within the vial of "inversin, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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