IGF-BP6 active protein
Human IGF-BP6
Gene Names
IGFBP6; IBP6
Reactivity
Human
Purity
>95% by SDS-PAGE and HPLC analysis
Synonyms
IGF-BP6; Human IGF-BP6; Recombinant Human IGF-BP6; IGF-BP6 active protein
Host
Insect Cells
Reactivity
Human
Purity/Purification
>95% by SDS-PAGE and HPLC analysis
Form/Format
Lyophilized
Sequence
RCPGCGQGVQ AGCPGGCVEE EDGGSPAEGC AEAEGCLRRE GQECGV YTPN CAPGLQCHPP KDDEAPLRAL LLGRGRCLPA RAPAVAEENP K ESKPQAGTA RPQDVNRRDQ QRNPGTSTTP SQPNSAGVQD TEMGPCR RHL DSVLQQLQTE VYRGAQTLYV PNCDHRGFYR KRQCRSSQGQ RR GPCWCVDR MGKSLPGSPD GNGSSSCPTG SSG
Sequence Length
240
Endotoxin Level
< 0.1 ng per ug of IGF-BP6
Biological Activity
Determined by its ability to inhibit IGF-II induced proliferation of human MCF-7 cells. The expected ED50 for this effect is 0.1 - 0.4 ug/ml.
Related Product Information for IGF-BP6 active protein
IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP6 is produced by bone cells and is the major IGF-BP present in cerebrospinal fluid, and specifically inhibits IGF-II actions. IGF-BP6 has been shown to inhibit IGF-II-dependent cancers such as neuroblastoma, colon cancer and rhabdomyosarcoma. Recombinant human IGF-BP6 has a calculated mass of 22.6 kDa and consists of 213 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain. IGF-BP6 migrates at an apparent molecular weight of approximately 23.0-30.0 kDa by SDS-PAGE analysis under non-reducing conditions.
Product Categories/Family for IGF-BP6 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
23-30 kDa
NCBI Official Full Name
insulin-like growth factor-binding protein 6
NCBI Official Synonym Full Names
insulin-like growth factor binding protein 6
NCBI Official Symbol
IGFBP6
NCBI Official Synonym Symbols
IBP6
NCBI Protein Information
insulin-like growth factor-binding protein 6; IBP-6; IGFBP-6; IGF binding protein 6; IGF-binding protein 6
UniProt Protein Name
Insulin-like growth factor-binding protein 6
UniProt Gene Name
IGFBP6
UniProt Synonym Gene Names
IBP6; IBP-6; IGF-binding protein 6; IGFBP-6
UniProt Entry Name
IBP6_HUMAN
Uniprot Description
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Subcellular location: Secreted.
Post-translational modification: O-linked glycans consist of hexose (probably Gal), N-acetylhexosamine (probably GalNAc) and sialic acid residues. O-glycosylated with core 1 or possibly core 8 glycans. O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid. Ref.10
Sequence similarities: Contains 1 IGFBP N-terminal domain.Contains 1 thyroglobulin type-1 domain.
Research Articles on IGF-BP6
Similar Products
Product Notes
The IGF-BP6 igfbp6 (Catalog #AAA691832) is an Active Protein produced from Insect Cells and is intended for research purposes only. The product is available for immediate purchase. The Human IGF-BP6 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: RCPGCGQGVQ AGCPGGCVEE EDGGSPAEGC AEAEGCLRRE GQECGV YTPN CAPGLQCHPP KDDEAPLRAL LLGRGRCLPA RAPAVAEENP K ESKPQAGTA RPQDVNRRDQ QRNPGTSTTP SQPNSAGVQD TEMGPCR RHL DSVLQQLQTE VYRGAQTLYV PNCDHRGFYR KRQCRSSQGQ RR GPCWCVDR MGKSLPGSPD GNGSSSCPTG SSG. It is sometimes possible for the material contained within the vial of "IGF-BP6, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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